Weese J Scott, Weese Heather E
Department of Pathobiology and Centre for Public Health and Zoonoses, Ontario Veterinary College, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G 2W1 (J.S. Weese); Conestoga College, 850 Fountain Street South, Cambridge, Ontario N3H 0A8 (H.E. Weese).
Can Vet J. 2025 Mar;66(3):327-334.
is a potential cause of brucellosis in humans, but this disease has been poorly characterized.
A scoping review was completed.
The review yielded 24 studies that described clinical infection in 68 individuals. The median age was 32 y (range: 17 mo to 71 y). Fever, fatigue, headache, chills, and malaise predominated.Specific treatments were reported for 30 individuals. A tetracycline (tetracycline, doxycycline, or minocycline) was the sole treatment or part of a combination treatment for most (21/30, 70%) individuals, followed by rifampin (9/30, 30%), trimethoprim/sulfamethoxazole (7/30, 23%), and an aminoglycoside (gentamicin, streptomycin) (7/30, 23%). Clinical outcome was reported for 35 individuals. No mortalities were reported.A known or suspected source of exposure was reported for 56 cases; 45 (80%) were linked to dogs and 11 (20%) to laboratory exposure. Contact with pet dogs that had aborted or with aborted fetuses accounted for 31% of the canine exposures.
Brucellosis attributed to can cause a wide range of clinical presentations in humans, but was similar to brucellosis caused by other spp. This nonspecific nature highlights the importance of identifying risk factors for exposure, to determine whether infection should be considered.
是人类布鲁氏菌病的一个潜在病因，但这种疾病的特征描述较少。
完成了一项范围综述。
该综述纳入了24项描述68例临床感染情况的研究。中位年龄为32岁（范围：17个月至71岁）。主要症状为发热、疲劳、头痛、寒战和不适。报告了30例患者的具体治疗情况。四环素（四环素、多西环素或米诺环素）是大多数（21/30，70%）患者的唯一治疗药物或联合治疗的一部分，其次是利福平（9/30，30%）、甲氧苄啶/磺胺甲恶唑（7/30，23%）和氨基糖苷类药物（庆大霉素、链霉素）（7/30，23%）。报告了35例患者的临床结局。未报告死亡病例。56例病例报告了已知或疑似暴露源；45例（80%）与狗有关，11例（20%）与实验室暴露有关。与流产的宠物狗或流产胎儿接触占犬类暴露的31%。
由引起的布鲁氏菌病可在人类中导致广泛的临床表现，但与其他种属引起的布鲁氏菌病相似。这种非特异性特征凸显了识别暴露风险因素以确定是否应考虑感染的重要性。
