Li Qiao, Tang Yang, Zuo Jie-Bin, Han Hao, Tu Guang-Xu, Chen Cheng
Department of Thoracic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Front Oncol. 2025 Feb 25;15:1521988. doi: 10.3389/fonc.2025.1521988. eCollection 2025.
Centromere protein H (CENP-H) is an important component of a functional centromere. Studies have demonstrated that CENP-H is overexpressed in renal cell, gastric, hypopharyngeal squamous cell, nasopharyngeal, endometrial, lung, cervical, esophageal, liver, colorectal, oral squamous cell, breast, and tongue carcinomas. CENP-H overexpression is positively correlated with a poor prognosis, pathological stage, T stage, and lymph node metastasis in patients with the above carcinomas. CENP-H can promote cancer growth and metastasis through PI3K/AKT, survivin, and mitochondrial apoptosis signaling mechanisms, and it can be regulated by long non-coding ribonucleic acid (lncRNA) plasmacytoma variant translocation 1 (PVT1)/miR-612, Sp1, or Sp3. This review aims to summarize the expression of CENP-H, the relationship between CENP-H expression and prognostic features, growth and metastasis of cancer in patients, as well as the mechanism of CENP-H in cancer. It also proposes a new candidate molecule for treating patients with cancer.
着丝粒蛋白H（CENP-H）是功能性着丝粒的重要组成部分。研究表明，CENP-H在肾细胞癌、胃癌、下咽鳞状细胞癌、鼻咽癌、子宫内膜癌、肺癌、宫颈癌、食管癌、肝癌、结直肠癌、口腔鳞状细胞癌、乳腺癌和舌癌中过表达。CENP-H过表达与上述癌症患者的不良预后、病理分期、T分期和淋巴结转移呈正相关。CENP-H可通过PI3K/AKT、生存素和线粒体凋亡信号机制促进癌症生长和转移，并且它可受长链非编码核糖核酸（lncRNA）浆细胞瘤变异易位1（PVT1）/miR-612、Sp1或Sp3调控。本综述旨在总结CENP-H的表达情况, CENP-H表达与患者癌症预后特征、生长和转移之间的关系，以及CENP-H在癌症中的作用机制。它还提出了一种治疗癌症患者的新候选分子。
