在定量构效关系（QSAR）研究中使用竞争性配体结合。
The use of competitive ligand binding results in QSAR studies.
作者信息
Gómez-Jeria J S
出版信息
Farmaco Sci. 1985 May;40(5):299-302.
PMID:4007152
Abstract
The use in QSAR studies of parameters measuring the ability of an unlabeled molecule to compete for the binding site with a radioligand is examined. It is shown that in order to employ them within a recently developed formal model it is previously necessary to carry out a linear transformation. This necessarily demands the adoption by investigators of a standard measuring procedure.
摘要
本文考察了在定量构效关系（QSAR）研究中使用未标记分子与放射性配体竞争结合位点能力的参数的情况。结果表明，为了在最近开发的形式模型中使用这些参数，事先必须进行线性变换。这必然要求研究人员采用标准的测量程序。
相似文献
1
The use of competitive ligand binding results in QSAR studies.在定量构效关系（QSAR）研究中使用竞争性配体结合。
Farmaco Sci. 1985 May;40(5):299-302.
2
QSAR: a critical appraisal.
NIDA Res Monogr. 1978(22):86-102.
3
Cocaine receptor--design of ligands.
NIDA Res Monogr. 1990;96:112-21.
4
Quantitative structure activity relationships of analgesics, narcotic antagonists, and hallucinogens: introduction.
NIDA Res Monogr. 1978(22):1-5.
5
Experimental procedure for estimating the dissociation constant of noncompetitive interactants. Part I.估算非竞争性相互作用剂解离常数的实验步骤。第一部分。
Boll Soc Ital Biol Sper. 1986 Jan 31;62(1):51-7.
6
Interactions of narcotics and their antagonists with human serum esterase. VII: Further studies on the affinity of drugs for the substrate-binding site of the enzyme.
Arch Int Pharmacodyn Ther. 1978 Jan;231(1):42-8.
7
[Morphinics receptors and endorphines (author's transl)].[吗啡受体与内啡肽（作者译）]
Rev Esp Anestesiol Reanim. 1981 Sep;28(5):293-300.
8
A chimeric analysis of the opioid receptor domains critical for the binding selectivity of mu opioid ligands.对μ阿片样物质配体结合选择性至关重要的阿片受体结构域的嵌合分析。
Neurobiol Dis. 1996 Feb;3(1):87-96. doi: 10.1006/nbdi.1996.0009.
9
[Receptor occupation theory and its parameter estimates (author's transl)].
Sheng Li Ke Xue Jin Zhan. 1981 Oct 25;12(4):318-24.
10
Analytical method for simultaneously measuring ex vivo drug receptor occupancy and dissociation rate: application to (R)-dimethindene occupancy of central histamine H1 receptors.同时测量离体药物受体占有率和解离速率的分析方法：应用于（R）-二甲茚定对中枢组胺H1受体的占有率
J Recept Signal Transduct Res. 2009;29(2):84-93. doi: 10.1080/10799890902721339.
Zotero 插件