Sambuco Nicola, Bradley Margaret M, Lang Peter J
Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy.
Department of Psychology, University of Florida, Gainesville, USA.
Psychophysiology. 2025 Mar;62(3):e70027. doi: 10.1111/psyp.70027.
Reductions in both the size of the amygdala and functional activity during emotional processing have been independently associated with trauma exposure and severity, raising the question of whether reduced volume prompts reduced functional activation. In this multimodal assessment, the relationship between amygdala structure and function was investigated in mood and anxiety patients to determine their covariation and their relationship to trauma magnitude. Overall, amygdala volume and functional emotional reactivity were unrelated, with smaller volumes and reduced emotional reactivity each independently predicting trauma magnitude for women, and mediation analysis did not support a hypothesis that the relationship between reduced functional activity and trauma severity depends on amygdala volume. Structural and functional differences were instead separately related to different facets of trauma experience, highlighting the need for longitudinal and multimodal analyses to further elucidate the relationship between brain structure, function, and psychopathology.
杏仁核体积减小以及情绪处理过程中的功能活动降低，均已分别与创伤暴露及严重程度相关联，这就引发了一个问题：体积减小是否会促使功能激活降低。在这项多模态评估中，研究了情绪和焦虑症患者杏仁核结构与功能之间的关系，以确定它们的协变关系以及与创伤程度的关系。总体而言，杏仁核体积与功能性情绪反应无关，体积较小和情绪反应降低各自独立预测女性的创伤程度，中介分析不支持功能活动降低与创伤严重程度之间的关系取决于杏仁核体积这一假设。相反，结构和功能差异分别与创伤经历的不同方面相关，这凸显了进行纵向和多模态分析以进一步阐明脑结构、功能与精神病理学之间关系的必要性。
