一种强大的线粒体微小蛋白：MOTS-c在急性肺损伤中的保护作用。 - Suppr

A Mighty Mitochondrial Microprotein: The Protective Role of MOTS-c in Acute Lung Injury.

作者信息

Kliment Corrine

机构信息

Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine University of Pittsburgh School of Medicine Pittsburgh, Pennsylvania.

出版信息

Am J Respir Cell Mol Biol. 2025 Sep;73(3):335-336. doi: 10.1165/rcmb.2025-0062ED.

DOI:10.1165/rcmb.2025-0062ED

PMID:40072017

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12416303/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22c6/12416303/07e1d7a6afd4/rcmb.2025-0062EDf1.jpg

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Alterations in circulating mitochondrial signals at hospital admission for COPD exacerbation.慢性阻塞性肺疾病（COPD）加重住院时循环线粒体信号的改变。

Chron Respir Dis. 2023 Jan-Dec;20:14799731231220058. doi: 10.1177/14799731231220058.

Mitochondrial microproteins: critical regulators of protein import, energy production, stress response pathways, and programmed cell death.线粒体小蛋白：蛋白输入、能量产生、应激反应途径和程序性细胞死亡的关键调节因子。

Am J Physiol Cell Physiol. 2023 Oct 1;325(4):C807-C816. doi: 10.1152/ajpcell.00189.2023. Epub 2023 Aug 29.

The mitochondrial-derived peptide MOTS-c suppresses ferroptosis and alleviates acute lung injury induced by myocardial ischemia reperfusion via PPARγ signaling pathway.线粒体衍生肽 MOTS-c 通过 PPARγ 信号通路抑制铁死亡，减轻心肌缺血再灌注引起的急性肺损伤。

Eur J Pharmacol. 2023 Aug 15;953:175835. doi: 10.1016/j.ejphar.2023.175835. Epub 2023 Jun 7.

Associations between serum mitokine levels and outcomes in stable COPD: an observational prospective study.稳定期 COPD 患者血清线粒体因子水平与结局的相关性：一项观察性前瞻性研究。

Sci Rep. 2022 Oct 15;12(1):17315. doi: 10.1038/s41598-022-21757-5.

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Nat Commun. 2021 Jan 20;12(1):470. doi: 10.1038/s41467-020-20790-0.

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The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance.线粒体衍生肽MOTS-c可促进代谢稳态，减轻肥胖和胰岛素抵抗。

Cell Metab. 2015 Mar 3;21(3):443-54. doi: 10.1016/j.cmet.2015.02.009.

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A Mighty Mitochondrial Microprotein: The Protective Role of MOTS-c in Acute Lung Injury.

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