Afridi Muhammad Irfan, Tu Haijun
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, Hunan University, Changsha 410082, China.
Shenzhen Research Institute, Hunan University, Shenzhen 518000, China.
Cells. 2025 Feb 21;14(5):327. doi: 10.3390/cells14050327.
Deleterious molecules or factors produced by pathogens can hinder the normal physiological functioning of organisms. In response to these survival challenges, organisms rely on innate immune signaling as their first line of defense, which regulates immune-responsive genes and antimicrobial peptides to protect against pathogenic infections. These genes are under the control of transcription factors, which are known to regulate the transcriptional activity of genes after binding to their regulatory sequences. Previous studies have employed as a host-pathogen interaction model to demonstrate the essential role of different transcription factors in the innate immunity of worms. In this review, we summarize the advances made regarding the functioning of distinct transcription factors in the innate immune response upon pathogen infection. Finally, we discuss the open questions in the field, whose resolutions have the potential to expand our understanding of the mechanisms underlying the innate immunity of organisms.
病原体产生的有害分子或因素会阻碍生物体的正常生理功能。为应对这些生存挑战，生物体依靠先天免疫信号作为其第一道防线，该防线调节免疫反应基因和抗菌肽以抵御病原体感染。这些基因受转录因子控制，已知转录因子在与调控序列结合后会调节基因的转录活性。先前的研究已将[具体内容缺失]用作宿主-病原体相互作用模型，以证明不同转录因子在蠕虫先天免疫中的重要作用。在本综述中，我们总结了病原体感染后不同转录因子在先天免疫反应中的功能进展。最后，我们讨论了该领域的开放性问题，解决这些问题有可能扩展我们对生物体先天免疫潜在机制的理解。
