Mangnall D, Clark R G
Int J Biochem. 1985;17(2):241-5. doi: 10.1016/0020-711x(85)90121-1.
Increases in glucose and urea output in response to increasing glucagon concentration have been studied in isolated livers perfused with physiological concentrations of amino acids. Glucose output was more sensitive to glucagon than urea output. A period of non-perfusion caused a subsequent loss of responsiveness to glucagon concentrations, at the high end of the physiological range, but the response to glucagon at the low end of the physiological range was unaffected. This probably represents a post-receptor effect rather than alterations at the receptor level.
在灌注生理浓度氨基酸的离体肝脏中，研究了随着胰高血糖素浓度升高，葡萄糖和尿素输出量的增加情况。葡萄糖输出量对胰高血糖素比尿素输出量更敏感。一段无灌注期导致随后对生理范围高端的胰高血糖素浓度失去反应性，但对生理范围低端的胰高血糖素反应不受影响。这可能代表一种受体后效应，而非受体水平的改变。
