Qin Hua-Di, Yang Yang, Xie Fei, Hou Lin, Gao Hui, Tang Jing-Wei, Shao Xiang-Sen, Qin Chun-Chang
Department of Anesthesiology, The First Affiliated Hospital of Chongqing Medical University, No.1 Youyi Road, Yuzhong District, Chongqing, 400016, China.
Department of Research and Development, APT Medical Inc. Langshan Road, Shenzhen, China.
J Cardiovasc Transl Res. 2025 Mar 12. doi: 10.1007/s12265-025-10601-6.
Acute postinfarction ventricular septum defect has a persistently high mortality rate due to unstable scars in the acute phase, which make surgery or occluder use unsuitable. Delayed closure increases the risk of irreversible hemodynamic deterioration. To address this, a dual latex balloon catheter was designed for temporary closure and tested in a pig model. The catheter, with a 10 French profile and 80 cm in length, includes two independent latex balloons and an anticoagulant channel to prevent thrombus formation. It was inserted via the jugular vein and guided over a 0.014-inch wire to straddle and seal the ventricular septum defect. In eight Yorkshire pigs with ventricular septum defects and acute myocardial infarction, the catheter effectively closed defects ranging from 6.1 to 10.5 mm for two weeks without complications. This innovative tool shows promise as a bridge therapy for managing acute postinfarction ventricular septum defect and warrants further evaluation.
急性心肌梗死后室间隔缺损由于急性期瘢痕不稳定，死亡率持续居高不下，这使得手术或使用封堵器并不合适。延迟闭合会增加不可逆血流动力学恶化的风险。为解决这一问题，设计了一种双乳胶球囊导管用于临时闭合，并在猪模型中进行了测试。该导管外径为10法国规格，长度为80厘米，包括两个独立的乳胶球囊和一个抗凝通道以防止血栓形成。它通过颈静脉插入，并在一根0.014英寸的导丝引导下跨骑并封闭室间隔缺损。在八只患有室间隔缺损和急性心肌梗死的约克夏猪中，该导管有效闭合了6.1至10.5毫米的缺损，持续两周且无并发症。这种创新工具作为治疗急性心肌梗死后室间隔缺损的桥接疗法显示出前景，值得进一步评估。
