Calmus Y, Biour M, Bodin F, Cheymol G, Darnis F
Gastroenterol Clin Biol. 1985 Mar;9(3):266-8.
The authors report two cases of hepatitis and a case of pancreatitis associated with indalpine. In one case of hepatitis, onset was acute and the clinical presentation was suggestive of cholecystitis; in the other case, hepatitis was discovered by biological tests. In the two cases, hepatitis was mainly cytolytic. Outcome was favorable upon interruption of drug administration. Onset of pancreatitis was inconspicuous, with progressively increasing pain. The pancreatic lesions were diffuse and massive. After interruption of administration, outcome was eventually favorable. Elevated amylasemia was also noted in the two cases of hepatitis. It is suggested that transaminase and amylase activities should be monitored during indalpine therapy.
作者报告了两例与茚达品相关的肝炎病例和一例胰腺炎病例。在其中一例肝炎中，起病急性，临床表现提示胆囊炎；在另一例中，肝炎通过生物学检查发现。在这两例中，肝炎主要为细胞溶解性。停药后结果良好。胰腺炎起病不明显，疼痛逐渐加重。胰腺病变弥漫且广泛。停药后，最终结果良好。在两例肝炎病例中也发现淀粉酶血症升高。建议在茚达品治疗期间监测转氨酶和淀粉酶活性。
