Liu Cong, Song Qing, Peng Ya-Ting, Cheng Wei, Lin Ling, Li Tao, Li Xue-Shan, Zeng Yu-Qin, Zhou Ai-Yuan, Chen Yan, Cai Shan, Chen Ping
Department of Pulmonary and Critical Care Medicine, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Research Unit of Respiratory Disease, Central South University, Changsha, Hunan, China.
Ann Med. 2025 Dec;57(1):2477299. doi: 10.1080/07853890.2025.2477299. Epub 2025 Mar 12.
Chronic Obstructive Pulmonary Disease (COPD) is a heterogeneous condition with different risk factors, including family history. This study aimed to explore association between a family history of chronic airway disease and features and outcomes of COPD.
Participants were obtained from the RealDTC study between December 2016 and December 2022. Data on demographics, pulmonary function, history of exacerbation at baseline, acute exacerbation during 1-year follow-up and survival status during 3-years follow-up were collected.
5020 patients were enrolled, with 1307 patients (26.0%) having a family history of chronic airway diseases. Compared with patients without a family history of chronic airway diseases, patients with a family history had a lower forced expiratory Volume in one second (FEV1), higher Modified Medical Research Council (mMRC) score and COPD Assessment Test (CAT) score, higher rate of acute exacerbation and hospitalization in the past year ( < 0.05) and rate of acute exacerbation and hospitalization during 1 year follow-up period ( < 0.05). It was an independent risk factor for acute exacerbation (OR = 2.196; 95% CI =1.873-2.576) and hospitalization (OR = 2.199; 95% CI =1.812-2.670). Over 3 years of follow-up, there were no significant differences in mortality rates and annual changes in FEV1 between two groups.
COPD patients with a family history of chronic airway disease are not rare, and they tend to have more severe symptoms and a higher risk of future deterioration. In the management of COPD, special attention should be paid to patients with a family history of chronic airway disease.
慢性阻塞性肺疾病（COPD）是一种具有不同风险因素的异质性疾病，包括家族史。本研究旨在探讨慢性气道疾病家族史与COPD的特征及预后之间的关联。
研究对象来自2016年12月至2022年12月的RealDTC研究。收集了人口统计学、肺功能、基线时的加重史、1年随访期间的急性加重情况以及3年随访期间的生存状况等数据。
共纳入5020例患者，其中1307例（26.0%）有慢性气道疾病家族史。与无慢性气道疾病家族史的患者相比，有家族史的患者一秒用力呼气容积（FEV1）较低，改良医学研究委员会（mMRC）评分和慢性阻塞性肺疾病评估测试（CAT）评分较高，过去一年的急性加重率和住院率较高（<0.05），以及1年随访期内的急性加重率和住院率较高（<0.05）。它是急性加重（比值比[OR]=2.196；95%置信区间[CI]=1.873 - 2.576）和住院（OR = 2.199；95% CI =1.812 - 2.670）的独立危险因素。在3年的随访中，两组的死亡率和FEV1的年度变化无显著差异。
有慢性气道疾病家族史的COPD患者并不罕见，他们往往有更严重的症状和未来病情恶化的较高风险。在COPD的管理中，应特别关注有慢性气道疾病家族史的患者。
