Sharma Mridula, Peter Varghese, Dennis Danielle, Raman Gitanjali, Purdy Suzanne C
College of Nursing and Health Sciences, Flinders University, Adelaide, Australia.
Department of Linguistics, Macquarie University, Sydney, Australia.
Eur J Neurosci. 2025 Mar;61(5):e70065. doi: 10.1111/ejn.70065.
The aim of the study was to determine the test-retest reliability of MMN and LDN recorded to simple speech contrasts in children with listening difficulties. MMN and LDN responses were recorded from Fz and Cz electrodes for a /da/-/ga/ contrast twice within a 10-day period. To extract MMN and LDN, auditory-evoked responses to /ga/ stimuli presented alone were subtracted from the responses to /ga/ presented within an oddball sequence. Intraclass correlation coefficients (ICCs) were used to determine test-retest reliability of MMN and LDN. Eighty-five children aged 7.0-12.8 years were grouped into four clusters; Cluster 1 included children with global difficulties (n = 34); Cluster 2 had children with poor auditory processing but relatively good word reading (n = 19); Cluster 3 had poor auditory processing, memory and attention skills but relatively good nonverbal intelligence and language skills (n = 14); and Cluster 4 had poor auditory processing and attention but relatively good memory skills (n = 18). At Visit 1, MMN and LDN were detectable at Cz in only 42% and 21% of participants, respectively. The ICC for the four clusters for MMN ranged from 0.36 to 0.76; LDN ICCs were 0.21-0.54. MMN was most replicable (71%) for children with listening difficulties in Cluster 3 with good nonverbal intelligence and language. The results do not support the clinical utility of MMN or LDN for objective assessment of auditory discrimination. Although MMN had better test-retest reliability, overall detectability was poor. Better detectability is required for any clinical utility in children.
本研究的目的是确定听力有困难的儿童对简单语音对比记录的失匹配负波（MMN）和失同步负波（LDN）的重测信度。在10天内，从Fz和Cz电极记录了两次MMN和LDN对/da/-/ga/对比的反应。为了提取MMN和LDN，将对单独呈现的/ga/刺激的听觉诱发反应从对在奇数序列中呈现的/ga/的反应中减去。组内相关系数（ICC）用于确定MMN和LDN的重测信度。85名年龄在7.0 - 12.8岁的儿童被分为四个组；第1组包括有全面困难的儿童（n = 34）；第2组有听觉处理能力差但单词阅读相对较好的儿童（n = 19）；第3组有听觉处理、记忆和注意力技能差但非言语智力和语言技能相对较好的儿童（n = 14）；第4组有听觉处理和注意力差但记忆技能相对较好的儿童（n = 18）。在第1次就诊时，分别只有42%和21%的参与者在Cz处可检测到MMN和LDN。四个组的MMN的ICC范围为0.36至0.76；LDN的ICC为0.21 - 0.54。对于第3组中具有良好非言语智力和语言能力的听力困难儿童，MMN的可重复性最高（71%）。结果不支持MMN或LDN在听觉辨别客观评估中的临床实用性。虽然MMN具有较好的重测信度，但总体可检测性较差。对于儿童的任何临床应用，都需要更好的可检测性。
