Gao Zehui, Jia Lina, Yao Jianli, Wang Chenxin, Huang-Fu Hui
First Hospital of Shanxi Medical University, Departent of Otorhinolaryngology, Head and Neck Surgery, Taiyuan, 030000, China.
Perioper Med (Lond). 2025 Mar 13;14(1):28. doi: 10.1186/s13741-025-00507-x.
Few studies have been published on the cognitive function and its relationship with quality of life (QoL) in patients with laryngeal squamous cell carcinoma (LSCC) undergoing surgery.
This study aimed to assess the association between changes in cognitive function perioperatively with QoL among patients with LSCC.
This was a prospective study. Eighty-eight cases with LSCC treated with radical surgery were assessed using the Montreal Cognitive Assessment (MoCA), Self-Rating Anxiety Scale (SAS), Self-Rating Depression Scale (SDS) and EORTC QLQ-C30. Statistical analysis was performed using SPSS 21.0 software.
The MoCA scores were 24.78 ± 2.42 before surgery and 23.02 ± 3.06 after surgery (p < 0.001). Correspondingly, 39 patients (44.32%) had cognitive impairment before surgery, and 47 patients (53.41%) had cognitive impairment after surgery. Age (p = 0.003) and preoperative anxiety (p = 0.016) were independent factors related to preoperative cognitive dysfunction, while age (p = 0.023), postoperative anxiety (p = 0.041), operation mode (p = 0.05, p = 0.016 respectively) and preoperative MoCA score (p = 0.008) were associated with postoperative cognitive dysfunction. Patients with cognitive impairment postoperatively had poorer QOL in the score of the overall health function scale (p = 0.030).
LSCC patients exhibit a high prevalence of cognitive dysfunction, which significantly associated with reduced overall QoL. Age, postoperative anxiety, operation mode, and preoperative MoCA score were significantly associated with postoperative cognitive dysfunction.
关于接受手术的喉鳞状细胞癌（LSCC）患者的认知功能及其与生活质量（QoL）的关系，发表的研究较少。
本研究旨在评估LSCC患者围手术期认知功能变化与QoL之间的关联。
这是一项前瞻性研究。采用蒙特利尔认知评估量表（MoCA）、自评焦虑量表（SAS）、自评抑郁量表（SDS）和欧洲癌症研究与治疗组织生活质量核心问卷（EORTC QLQ-C30）对88例行根治性手术治疗的LSCC患者进行评估。使用SPSS 21.0软件进行统计分析。
MoCA评分术前为24.78±2.42，术后为23.02±3.06（p<0.001）。相应地，术前有39例患者（44.32%）存在认知障碍，术后有47例患者（53.41%）存在认知障碍。年龄（p=0.003）和术前焦虑（p=0.016）是与术前认知功能障碍相关的独立因素，而年龄（p=0.023）、术后焦虑（p=0.041）、手术方式（分别为p=0.05、p=0.016）和术前MoCA评分（p=0.008）与术后认知功能障碍有关。术后有认知障碍的患者在总体健康功能量表评分中的QOL较差（p=0.030）。
LSCC患者认知功能障碍的患病率较高，这与总体QoL降低显著相关。年龄、术后焦虑、手术方式和术前MoCA评分与术后认知功能障碍显著相关。
