Luo Xiaoqiong, Ding Qidi, Liu Yanan, Han Fang, Li Chenyu, Dong Xiaosong
Department of Encephalopathy, Chongqing Traditional Chinese Medicine Hospital, Chongqing, 400021, China.
Department of Respiratory and Sleep Medicine, Peking University People's Hospital, Beijing, 100044, China.
J Med Case Rep. 2025 Mar 12;19(1):112. doi: 10.1186/s13256-025-05111-7.
Baclofen can relax muscle spasticity by inhibiting the transmission of both mono- and polysynaptic reflexes at the spinal cord. It has been increasingly used off-label for the management of spinal cord lesions or neurologic disorders. However, the expansion use has led to an increase in baclofen-associated complications.
We report the case of a 60-year-old Chinese female patient who suffered from nocturnal choking and daytime sleepiness. Polysomnography identified central sleep apnea after initiation of low-dosage baclofen (10 mg two times a day) treatment, and a complete resolution of central sleep apnea was associated with baclofen withdrawal.
This case reminds us that more attention should be paid to the adverse reactions on respiratory control of baclofen, even with low dosage. Regular polysomnography before and after prescription of baclofen is helpful to detect the effects of baclofen on sleep and breathing.
巴氯芬可通过抑制脊髓单突触和多突触反射的传递来缓解肌肉痉挛。它越来越多地被用于脊髓损伤或神经系统疾病的非标签治疗。然而，这种扩展使用导致了巴氯芬相关并发症的增加。
我们报告了一名60岁中国女性患者的病例，该患者患有夜间窒息和日间嗜睡。多导睡眠监测发现在开始低剂量巴氯芬（每日两次，每次10毫克）治疗后出现中枢性睡眠呼吸暂停，且停用巴氯芬后中枢性睡眠呼吸暂停完全缓解。
该病例提醒我们，即使是低剂量的巴氯芬，也应更加关注其对呼吸控制的不良反应。在开具巴氯芬处方前后进行定期多导睡眠监测，有助于检测巴氯芬对睡眠和呼吸的影响。
