低剂量巴氯芬引起的中枢性睡眠呼吸暂停：一例报告

Central sleep apnea caused by low dosage of baclofen: a case report.

作者信息

Luo Xiaoqiong, Ding Qidi, Liu Yanan, Han Fang, Li Chenyu, Dong Xiaosong

机构信息

Department of Encephalopathy, Chongqing Traditional Chinese Medicine Hospital, Chongqing, 400021, China.

Department of Respiratory and Sleep Medicine, Peking University People's Hospital, Beijing, 100044, China.

出版信息

J Med Case Rep. 2025 Mar 12;19(1):112. doi: 10.1186/s13256-025-05111-7.

DOI:10.1186/s13256-025-05111-7

PMID:40075445

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11905528/

Abstract

BACKGROUND

Baclofen can relax muscle spasticity by inhibiting the transmission of both mono- and polysynaptic reflexes at the spinal cord. It has been increasingly used off-label for the management of spinal cord lesions or neurologic disorders. However, the expansion use has led to an increase in baclofen-associated complications.

CASE PRESENTATION

We report the case of a 60-year-old Chinese female patient who suffered from nocturnal choking and daytime sleepiness. Polysomnography identified central sleep apnea after initiation of low-dosage baclofen (10 mg two times a day) treatment, and a complete resolution of central sleep apnea was associated with baclofen withdrawal.

CONCLUSION

This case reminds us that more attention should be paid to the adverse reactions on respiratory control of baclofen, even with low dosage. Regular polysomnography before and after prescription of baclofen is helpful to detect the effects of baclofen on sleep and breathing.

摘要