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Figure 16 synthesizes the various aspects of marrow egress. The central anatomical relationship of the hematopoietic compartment to vascular sinus is shown above. The hatched blocks represent the sinus wall, capable of developing narrow migration channels. In the marrow, immature granulocytes alter their biophysical characteristics by developing motility, nuclear and cytoplasmic deformability and surfaces which facilitate egress. Humoral factors contribute to proliferation and maturation. Also, other humoral agents, releasing factors, may act on mature cells, for example, as cytoattractants, and on the sinus wall to reduce its adventitial cover and thereby to enhance egress. In the sinus, flow or discharge of sinus contents may be regulated by humoral agents or neural messages which may affect terminal sphincters or other structures. Although the marrow in situ is a difficult organ to study, future innovations are to be expected and our understanding of the delicate balance between hematopoietic cells, stroma and vasculature will be enhanced. Corrections of inferential errors due in part to the semi-quantitative and qualitative nature of much of our current data should be expected.
图16综合了骨髓输出的各个方面。上方展示了造血腔室与血管窦的中心解剖关系。阴影块代表能够形成狭窄迁移通道的窦壁。在骨髓中，未成熟粒细胞通过发展运动性、核与细胞质的可变形性以及便于输出的表面来改变其生物物理特性。体液因子有助于增殖和成熟。此外，其他体液因子，即释放因子，可能作用于成熟细胞，例如作为细胞吸引剂，也作用于窦壁以减少其外膜覆盖，从而增强输出。在窦内，窦内容物的流动或排出可能受体液因子或神经信号调节，这些因子或信号可能影响终末括约肌或其他结构。尽管原位骨髓是一个难以研究的器官，但有望出现未来的创新成果，我们对造血细胞、基质和脉管系统之间微妙平衡的理解也将得到增强。应该预期能够纠正部分由于我们当前许多数据的半定量和定性性质所导致的推断错误。
