2-β-D-呋喃核糖基噻唑-4-甲酰胺（替加氟核苷）在小鼠异种移植试验中对未经治疗的人类卵巢癌的作用。
Action of 2-beta-D-ribofuranosylthiazole-4-carboxamide (tiazofurin) against untreated human ovarian cancers in the murine xenograft assay.
作者信息
Micha J P, Kucera P R, Preve C U, Rettenmaier M A, Stratton J A, DiSaia P J
出版信息
Gynecol Oncol. 1985 Jul;21(3):351-5. doi: 10.1016/0090-8258(85)90273-2.
PMID:4007612
Abstract
The activity of 2-beta-D-ribofuranosylthiazole-4-carboxamide (tiazofurin) was determined in nine untreated human ovarian cancer specimens, using the murine subrenal capsule xenograft assay. Tumor cytotoxic effect was demonstrated in seven out of the nine tumors implanted. The drug was well tolerated by the test animals. Tiazofurin may prove to be an effective chemotherapeutic agent in the treatment of ovarian cancer.
摘要
使用小鼠肾包膜下异种移植试验，对9个未经治疗的人类卵巢癌标本中2-β-D-呋喃核糖基噻唑-4-甲酰胺（替拉扎明）的活性进行了测定。在植入的9个肿瘤中有7个显示出肿瘤细胞毒性作用。试验动物对该药物耐受性良好。替拉扎明可能被证明是治疗卵巢癌的一种有效化疗药物。
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