Miura Y, Inui J, Nakamura T
Nihon Yakurigaku Zasshi. 1985 Mar;85(3):159-65. doi: 10.1254/fpj.85.159.
Effects of nizofenone, an agent which has been known to have a protective effect against experimental cerebral ischemia or anoxia, on the action potential of guinea-pig papillary muscle and S-A node and dog Purkinje fibers were studied. Nizofenone (10(-6) and 10(-5) M) significantly prolonged the action potential duration of guinea-pig papillary muscle and dog Purkinje fibers accompanying prolongation of the effective refractory period in dog Purkinje fibers. Nizofenone decreased Vmax at the concentrations of 10(-5) and 10(-4) M in guinea-pig papillary muscle and at 10(-4) M in dog Purkinje fibers. Nizofenone suppressed the spontaneous activity of dog Purkinje fibers and guinea-pigs S-A node at the concentrations of 3 X 10(-5) to 10(-4) M and 10(-5) M, respectively. Nizofenone (10(-4) M) decreased the contractile force of guinea-pig papillary muscle. In the guinea-pig papillary muscle, the effect of nizofenone on action potential duration was almost the same as that of quinidine, but the inhibitory effect on Vmax was slightly weaker than quinidine. These results suggest that nizofenone has a so-called "quinidine-like action" on cardiac membrane.
已知具有抗实验性脑缺血或缺氧保护作用的尼唑苯酮，对豚鼠乳头肌、窦房结及犬浦肯野纤维动作电位的影响进行了研究。尼唑苯酮（10⁻⁶和10⁻⁵M）显著延长豚鼠乳头肌和犬浦肯野纤维的动作电位时程，同时延长犬浦肯野纤维的有效不应期。在豚鼠乳头肌中，尼唑苯酮浓度为10⁻⁵和10⁻⁴M时以及在犬浦肯野纤维中浓度为10⁻⁴M时，可降低Vmax。尼唑苯酮分别在浓度为3×10⁻⁵至10⁻⁴M和10⁻⁵M时，抑制犬浦肯野纤维和豚鼠窦房结的自发活动。尼唑苯酮（10⁻⁴M）降低豚鼠乳头肌的收缩力。在豚鼠乳头肌中，尼唑苯酮对动作电位时程的影响与奎尼丁几乎相同，但对Vmax的抑制作用略弱于奎尼丁。这些结果表明，尼唑苯酮对心肌膜具有所谓的“奎尼丁样作用”。
