富马酸尼唑苯酮对家兔离体窦房结的变时性作用。
Chronotropic effect of nizofenone fumarate in rabbit sino-atrial node in vitro.
作者信息
Kotake H, Nawada T, Matsumoto T, Kitamura H, Kaneda T, Hasegawa J, Mashiba H
机构信息
1st Department of Internal Medicine, Tottori University, Yonago, Japan.
出版信息
Br J Pharmacol. 1988 Dec;95(4):1175-80. doi: 10.1111/j.1476-5381.1988.tb11753.x.
Abstract
- The effects of nizofenone fumarate were studied on the membrane potentials and currents of rabbit sino-atrial node preparations by means of the double-microelectrode voltage clamp method. 2. In spontaneously firing pacemaker cells, nizofenone (above 1 microM) decreased the heart rate. Above 3 microM, nizofenone reduced the maximum upstroke velocity, the amplitude of the action potential and the slope of the phase 4 depolarization, and prolonged the action potential duration at 50% repolarization. 3. Under voltage clamp conditions, nizofenone decreased the slow inward current and the time-dependent potassium outward current in a dose-dependent manner. 4. These findings suggest that nizofenone exerts an inhibitory action on the automaticity of sinoatrial node preparations via effects on both inward and outward currents.
摘要
- 采用双微电极电压钳法研究了富马酸尼唑苯酮对兔窦房结标本膜电位和电流的影响。2. 在自律性起搏细胞中，尼唑苯酮（浓度高于1微摩尔/升）可降低心率。浓度高于3微摩尔/升时，尼唑苯酮可降低最大除极速度、动作电位幅度和4期去极化斜率，并延长50%复极化时的动作电位持续时间。3. 在电压钳条件下，尼唑苯酮以剂量依赖方式降低慢内向电流和时间依赖性钾外向电流。4. 这些结果表明，尼唑苯酮通过对内向和外向电流的作用，对窦房结标本的自律性产生抑制作用。
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本文引用的文献
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