Fernández-Morales Carlos, Espejo-Antúnez Luis, Albornoz-Cabello Manuel, Yáñez-Álvarez Ángel Rufino, Cardero-Durán María de Los Ángeles
Department of Medical-Surgical Therapy, Faculty of Medicine and Health Sciences, University of Extremadura, 06006 Badajoz, Spain.
Department of Physiotherapy, University of Seville, 41009 Seville, Spain.
Healthcare (Basel). 2025 Feb 26;13(5):509. doi: 10.3390/healthcare13050509.
Chronic pain has been reported as one of the leading causes of disability in the world, being associated with a potential impact on autonomic balance.
The aim was to compare sympathetic and parasympathetic activity through heart rate variability (HRV) between adults with and without chronic low back pain (CLBP).
An observational study was conducted in which HRV parameters were recorded using time-domain measures-root mean square of successive differences between consecutive RR intervals (rMSSD), minimum and maximum heart rate variability (Min HR and Max HR), and mean heart rate (Mean HR)-and nonlinear measures-Poincaré plot indices SD1 and SD2, Stress Score (SS), and sympathetic/parasympathetic ratio (S:PS).
The results showed statistically significant differences between groups ( < 0.05), with higher parasympathetic activity parameters in the group of healthy subjects (rMSSD: < 0.001; SD1: = 0.030) and higher sympathetic activity in the CLBP group (SD2, SS, and S:PS ratio: < 0.001). All parameters showed large effect sizes.
These findings show the association between autonomic balance mechanisms and pain regulation in adults with CLBP.
慢性疼痛已被报道为全球致残的主要原因之一,与自主神经平衡的潜在影响相关。
旨在通过心率变异性(HRV)比较慢性下腰痛(CLBP)成人与无慢性下腰痛成人的交感神经和副交感神经活动。
进行了一项观察性研究,使用时域测量记录HRV参数——连续RR间期之间连续差值的均方根(rMSSD)、最小和最大心率变异性(Min HR和Max HR)以及平均心率(Mean HR),以及非线性测量——庞加莱图指数SD1和SD2、应激评分(SS)和交感神经/副交感神经比率(S:PS)。
结果显示两组之间存在统计学显著差异(<0.05),健康受试者组的副交感神经活动参数较高(rMSSD:<0.001;SD1:=0.030),而CLBP组的交感神经活动较高(SD2、SS和S:PS比率:<0.001)。所有参数均显示出较大的效应量。
这些发现表明CLBP成人的自主神经平衡机制与疼痛调节之间存在关联。