Sim So-Yeon, Cho Hyun-Dong, Lee Sae-Byuk
School of Food Science and Biotechnology, Kyungpook National University, 80 Daehak-ro, Daegu 41566, Republic of Korea.
Department of Food and Nutrition, Sunchon National University, Sunchon 57922, Republic of Korea.
Foods. 2025 Mar 3;14(5):861. doi: 10.3390/foods14050861.
Alcoholic hepatic steatosis (AHS) is a common early-stage symptom of liver disease caused by alcohol consumption. Accordingly, several aspects of AHS have been studied as potential preventive and therapeutic targets. In this study, a novel strategy was employed to inhibit fatty liver accumulation and counteract AHS through the consumption of microorganism-fermented larvae (FPBs). By using an AHS rat model, we assessed the efficacy of FPB by examining the lipid profile of liver/serum and liver function tests to evaluate lipid metabolism modulation. After FPB administration, the lipid profile-including high-density lipoprotein, total cholesterol, and total triglycerides-and histopathological characteristics exhibited improvement in the animal model. Interestingly, AHS amelioration via FPBs administration was potentially associated with poly-γ-glutamic acid (PγG), which is produced by species during fermentation. These findings support the formulation of novel natural remedies for AHS through non-clinical animal studies, suggesting that PγG-enriched FPBs are a potentially valuable ingredient for functional foods, providing an ameliorative effect on AHS.
酒精性肝脂肪变性（AHS）是饮酒引起的肝脏疾病常见的早期症状。因此，AHS的几个方面已被作为潜在的预防和治疗靶点进行研究。在本研究中，采用了一种新策略，即通过食用微生物发酵幼虫（FPBs）来抑制脂肪肝积累并对抗AHS。通过使用AHS大鼠模型，我们通过检查肝脏/血清的脂质谱和肝功能测试来评估脂质代谢调节，从而评估FPB的功效。给予FPB后，动物模型中的脂质谱（包括高密度脂蛋白、总胆固醇和总甘油三酯）和组织病理学特征均有改善。有趣的是，通过给予FPB改善AHS可能与发酵过程中由该物种产生的聚γ-谷氨酸（PγG）有关。这些发现通过非临床动物研究支持了针对AHS的新型天然疗法的制定，表明富含PγG的FPB是功能性食品的潜在有价值成分，对AHS具有改善作用。
