Oyardı Pelin, Ural Ülkü Mete
Department of Obstetrics and Gynecology, Baykan State Hospital, Siirt, Türkiye.
Department of Obstetrics and Gynecology, Bolu Abant İzzet Baysal University Faculty of Medicine, Bolu, Türkiye.
J Turk Ger Gynecol Assoc. 2025 Mar 12;26(1):15-19. doi: 10.4274/jtgga.galenos.2024.2024-5-6.
The aim of this study was to investigate the efficacy of injectable, platelet-rich fibrin (PRF) for the treatment of vaginal atrophy, also known as genitourinary syndrome of menopause (GSM), which may affect a third of a woman's lifespan.
This study included postmenopausal patients who had symptoms of genitourinary syndrome, such as vaginal burning, dryness, itching, and sexual dysfunction. Injectable platelet-rich fibrin (i-PRF) was applied to three areas on the posterior vaginal wall twice, one month apart. The genitourinary symptoms of the patients were evaluated using the female sexual function index (FSFI) and sexual life quality questionnaire before and one and six months after the procedure.
Thirty-five patients were recruited with a mean age of 54.1±5.5 years. The analysis of the desire, arousal, lubrication, orgasm, satisfaction, pain, and total scores of the pre-procedural and post-procedural FSFI and sexual life quality questionnaire scores revealed significant improvements (p<0.001).
i-PRF treatment provided advantages such as safe and easy application, autologous material nature, absence of procedure-related complications or side effects, short procedure time, absence of the need for hospitalization, low cost, and a non-hormonal nature. These results suggest that injectable, PRF may be a promising treatment option in patients with symptoms of GSM. However, larger randomized controlled studies are needed to confirm and validate our findings.
本研究旨在探讨注射用富血小板纤维蛋白（PRF）治疗阴道萎缩（也称为绝经后泌尿生殖综合征，GSM）的疗效，该综合征可能影响女性三分之一的寿命。
本研究纳入有泌尿生殖综合征症状（如阴道烧灼感、干燥、瘙痒和性功能障碍）的绝经后患者。将注射用富血小板纤维蛋白（i-PRF）分两次应用于阴道后壁的三个区域，间隔一个月。在手术前、术后1个月和6个月，使用女性性功能指数（FSFI）和性生活质量问卷对患者的泌尿生殖症状进行评估。
招募了35名患者，平均年龄为54.1±5.5岁。对术前和术后FSFI及性生活质量问卷评分中的欲望、唤起、润滑、性高潮、满意度、疼痛和总分进行分析，结果显示有显著改善（p<0.001）。
i-PRF治疗具有安全易用、自体材料性质、无手术相关并发症或副作用、手术时间短、无需住院、成本低和非激素性质等优点。这些结果表明，注射用PRF可能是GSM症状患者一种有前景的治疗选择。然而，需要更大规模的随机对照研究来证实和验证我们的发现。
