Sleeper Geoffery P, Catullo Kimber A, Chen Pai-Lien, Patil Susheel P, Strohl Kingman P, Chiang Ambrose A
BRYGGS Medical, Avon, Ohio.
Simulation and Advanced Skills Center, Cleveland Clinic, Cleveland, Ohio.
J Clin Sleep Med. 2025 Jun 1;21(6):1073-1079. doi: 10.5664/jcsm.11624.
Despite its efficacy, long-term adherence to continuous positive airway pressure (CPAP) hovers around 50%. The V-Com (SleepRes, Murfreesboro, TN), an inspiratory pressure relief (IPR) accessory, claims to improve comfort by decreasing inspiratory pressures. We aim to independently assess its impact on fixed CPAP settings in a laboratory bench model.
An ASL-5000 Breathing simulator (IngMar Medical, Pittsburgh, PA) with normal lung settings was employed. A ResMed AirSense 11 device was connected to ASL-5000 through a React Health Rio II exhalation vent and an elbow adapter. Mean inspiratory and expiratory pressures were measured at fixed CPAP settings (4, 6, 8, 10, 12, 14, 16, 18, and 20 cm HO) at baseline, 1 IPR unit, and 2 IPR units in series, without and with expiratory pressure relief. Generalized linear models were applied to evaluate changes in pressure across CPAP settings.
With 1 IPR, mean inspiratory pressures decreased significantly from the baseline pressures ( < .001), with only a marginal reduction of mean expiratory pressures ( = .239). The inspiratory pressure reduction was consistently greater than the expiratory pressure drop across all settings ( < .001). Higher CPAP settings resulted in larger reductions in inspiratory and expiratory pressures ( < .001). Two IPR units in series led to a greater decrease in both pressures ( = .001). When expiratory pressure relief 3 was combined with IPR, a larger drop in pressure was noted ( < .001).
This IPR accessory decreases inspiratory pressures but only marginally reduces expiratory pressures in this laboratory bench model. Two IPR units further decrease both inspiratory and expiratory pressures.
Sleeper GP, Catullo KA, Chen P-L, Patil SP, Strohl KP, Chiang AA. The influence of an innovative inspiratory pressure relief accessory on continuous positive airway pressure profiles in a laboratory bench setting. . 2025;21(6):1073-1079.
尽管持续气道正压通气（CPAP）疗效显著，但其长期依从性仅徘徊在50%左右。吸气压力释放（IPR）配件V-Com（SleepRes，田纳西州默弗里斯伯勒）宣称可通过降低吸气压力来提高舒适度。我们旨在通过实验室台架模型独立评估其对固定CPAP设置的影响。
采用设置正常肺部参数的ASL-5000呼吸模拟器（英格玛医疗公司，宾夕法尼亚州匹兹堡）。瑞思迈AirSense 11设备通过React Health Rio II呼气口和弯头适配器连接到ASL-5000。在基线、1个IPR单元和2个串联的IPR单元状态下，于固定CPAP设置（4、6、8、10、12、14、16、18和20 cm H₂O）时测量平均吸气和呼气压力，测量时有无呼气压力释放。应用广义线性模型评估不同CPAP设置下的压力变化。
使用1个IPR时，平均吸气压力较基线压力显著降低（P <.001），而平均呼气压力仅略有降低（P =.239）。在所有设置下，吸气压力的降低始终大于呼气压力的下降（P <.001）。较高的CPAP设置导致吸气和呼气压力的降幅更大（P <.001）。2个串联的IPR单元使两种压力均有更大程度的降低（P =.001）。当呼气压力释放与IPR联合使用时，压力下降幅度更大（P <.001）。
在该实验室台架模型中，这种IPR配件可降低吸气压力，但仅略微降低呼气压力。2个IPR单元可进一步降低吸气和呼气压力。
Sleeper GP, Catullo KA, Chen P-L, Patil SP, Strohl KP, Chiang AA. 创新型吸气压力释放配件对实验室台架设置下持续气道正压通气参数的影响。《[期刊名称]》。2025；21(6):1073 - 1079。
