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Leukemic presentation in nodal mantle cell lymphoma is characterized by frequent SOX11 negativity, a poor risk genomic landscape including higher TP53 alterations, and worse overall survival.

作者信息

Yan Mingfei, Sethi Shenon, Kumar Jyoti, Kumar Anita, Dogan Ahmet, Galera Pallavi

机构信息

Hematopathology Service, Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.

Hematopathology Service, Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Diagnostic Molecular Pathology Service, Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.

出版信息

Haematologica. 2025 Sep 1;110(9):2209-2213. doi: 10.3324/haematol.2024.287108. Epub 2025 Mar 13.

DOI:10.3324/haematol.2024.287108
PMID:40079077
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12399956/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4efe/12399956/8f852ed21a59/1102209.fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4efe/12399956/031b2e1100d1/1102209.fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4efe/12399956/24c864faa820/1102209.fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4efe/12399956/8f852ed21a59/1102209.fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4efe/12399956/031b2e1100d1/1102209.fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4efe/12399956/24c864faa820/1102209.fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4efe/12399956/8f852ed21a59/1102209.fig3.jpg

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1
Leukemic presentation in nodal mantle cell lymphoma is characterized by frequent SOX11 negativity, a poor risk genomic landscape including higher TP53 alterations, and worse overall survival.结外套细胞淋巴瘤的白血病表现特征为SOX11常呈阴性、具有包括较高TP53改变在内的不良风险基因组格局以及较差的总生存期。
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本文引用的文献

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IndiSPENsable for X Chromosome Inactivation and Gene Silencing.对于X染色体失活和基因沉默不可或缺。
Epigenomes. 2023 Nov 2;7(4):28. doi: 10.3390/epigenomes7040028.
2
19-color, 21-Antigen Single Tube for Efficient Evaluation of B- and T-cell Neoplasms.19 色、21 抗原单管，用于高效评估 B 细胞和 T 细胞肿瘤。
Curr Protoc. 2023 Sep;3(9):e884. doi: 10.1002/cpz1.884.
3
NOTCH Signaling in Mantle Cell Lymphoma: Biological and Clinical Implications.NOTCH 信号通路在套细胞淋巴瘤中的作用：生物学与临床意义。
Int J Mol Sci. 2023 Jun 17;24(12):10280. doi: 10.3390/ijms241210280.
4
Genomic and transcriptomic profiling reveals distinct molecular subsets associated with outcomes in mantle cell lymphoma.基因组和转录组谱分析揭示与套细胞淋巴瘤患者结局相关的不同分子亚群。
J Clin Invest. 2022 Feb 1;132(3). doi: 10.1172/JCI153283.
5
Enhanced specificity of clinical high-sensitivity tumor mutation profiling in cell-free DNA via paired normal sequencing using MSK-ACCESS.基于 MSK-ACCESS 的配对正常测序提高了游离 DNA 中临床高敏肿瘤突变分析的特异性。
Nat Commun. 2021 Jun 18;12(1):3770. doi: 10.1038/s41467-021-24109-5.
6
Poorly differentiated chordoma with whole-genome doubling evolving from a SMARCB1-deficient conventional chordoma: A case report.分化不良的 chordoma 伴全基因组倍增，由 SMARCB1 缺陷型常规 chordoma 演进而来：病例报告。
Genes Chromosomes Cancer. 2021 Jan;60(1):43-48. doi: 10.1002/gcc.22895. Epub 2020 Oct 7.
7
SOX11 promotes tumor protective microenvironment interactions through CXCR4 and FAK regulation in mantle cell lymphoma.SOX11 通过调节 CXCR4 和 FAK 促进套细胞淋巴瘤肿瘤保护性微环境相互作用。
Blood. 2017 Jul 27;130(4):501-513. doi: 10.1182/blood-2017-04-776740. Epub 2017 May 22.
8
Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT): A Hybridization Capture-Based Next-Generation Sequencing Clinical Assay for Solid Tumor Molecular Oncology.纪念斯隆凯特琳癌症中心可操作癌症靶点综合突变分析（MSK-IMPACT）：一种基于杂交捕获的实体瘤分子肿瘤学新一代测序临床检测方法。
J Mol Diagn. 2015 May;17(3):251-64. doi: 10.1016/j.jmoldx.2014.12.006. Epub 2015 Mar 20.
9
Prognostic role of SOX11 in a population-based cohort of mantle cell lymphoma.SOX11 在基于人群的套细胞淋巴瘤队列中的预后作用。
Blood. 2012 May 3;119(18):4215-23. doi: 10.1182/blood-2011-12-400580. Epub 2012 Mar 19.
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Haematologica. 2012 Sep;97(9):1422-30. doi: 10.3324/haematol.2011.055715. Epub 2012 Feb 7.