Wal J M, Meslin J C, Weyer A, David B
Int Arch Allergy Appl Immunol. 1985;77(3):308-14. doi: 10.1159/000233836.
The distributions of histamine and mast cells in the intestinal mucosa have been studied in conventional (CV) and germ-free (GF) rats. Both distributions do not appear to be uniform throughout the gastrointestinal tract. The presence of digestive microflora influences these distributions: more histamine and mucosal mast cells are present in the small intestine of CV than in GF rats. Paradoxically the opposite is observed in the large intestine. Differences in mast cell counts in the crypt area of the small intestine (higher in CV than in GF rats) confirm the role of microflora on crypt cell proliferation due to a mild chronic inflammation. In the large intestine, however, the microflora appears to have a more complex influence and could act indirectly on histamine turnover.
已对常规饲养（CV）和无菌（GF）大鼠肠道黏膜中组胺和肥大细胞的分布进行了研究。在整个胃肠道中，这两种分布似乎都不均匀。消化微生物群的存在会影响这些分布：CV大鼠小肠中的组胺和黏膜肥大细胞比GF大鼠中的更多。矛盾的是，在大肠中观察到的情况则相反。小肠隐窝区域肥大细胞计数的差异（CV大鼠高于GF大鼠）证实了微生物群由于轻度慢性炎症对隐窝细胞增殖的作用。然而，在大肠中，微生物群似乎具有更复杂的影响，并且可能间接作用于组胺代谢。
