Wingren U
Agents Actions. 1984 Jun;14(5-6):598-601. doi: 10.1007/BF01978892.
The uptake and elimination of radiolabelled histamine was studied in the rat duodenum, where histamine is stored in a specific population of mucosal mast cells (MMC), and in the tongue, where histamine is stored in the classic connective tissue mast cell (CTMC). The specific activity of histamine was measured after one i.v. injection of its precursor, 3H-histidine. Decarboxylation of histidine and uptake of histamine occurred in both tissues. The initial specific activity of histamine was very low in the tongue but 5 times higher in the duodenum, while the endogenous duodenal histamine content was 1/6 of that in the tongue. The elimination rate of labelled histamine in the two mast cell pools was very slow. In the tongue, there was no statistically significant decrease in specific activity during the observation period of 16 days. In the duodenum, there was an exponential decrease of prelabelled histamine with an apparent half-life of 9 days. However, part of this decay of radioactivity may be accounted for by increase in the mucosal histamine pool size and MMC death. The results indicate that the rate of histamine elimination from mast cells of both types is very slow, corresponding with previous results obtained from CTMC of the peritoneal cavity.
在大鼠十二指肠（组胺储存于特定的黏膜肥大细胞群中）和舌头（组胺储存于经典的结缔组织肥大细胞中）中研究了放射性标记组胺的摄取和消除情况。静脉注射其前体3H-组氨酸后，测定组胺的比活性。组氨酸脱羧和组胺摄取在两种组织中均有发生。组胺的初始比活性在舌头中非常低，但在十二指肠中高5倍，而十二指肠内源性组胺含量是舌头中的1/6。两个肥大细胞池中标记组胺的消除速率非常缓慢。在舌头中，在16天的观察期内比活性没有统计学上的显著下降。在十二指肠中，预标记组胺呈指数下降，表观半衰期为9天。然而，这种放射性衰减的一部分可能是由于黏膜组胺池大小的增加和黏膜肥大细胞死亡所致。结果表明，两种类型肥大细胞中组胺的消除速率非常缓慢，这与先前从腹膜腔结缔组织肥大细胞获得的结果一致。
