Kang Letian, Li Xuan, Zhao Xin, Liu Ting, Jin Ye, Duan Yan
College of Food Science and Engineering, Inner Mongolia Agricultural University, Hohhot 010018, China; Integrative Research Base of Beef and Lamb Processing Technology, Ministry of Agriculture and Rural Affairs of the People's Republic of China, Hohhot 010018, China.
College of Food Science and Engineering, Inner Mongolia Agricultural University, Hohhot 010018, China; Integrative Research Base of Beef and Lamb Processing Technology, Ministry of Agriculture and Rural Affairs of the People's Republic of China, Hohhot 010018, China.
Food Chem. 2025 Jul 1;479:143677. doi: 10.1016/j.foodchem.2025.143677. Epub 2025 Mar 6.
Arginine (ARG) improves meat quality and fat deposition; however, its effects on gut microbiota-mediated lipid metabolism in lambs remain unclear. Twenty-four lambs were divided into control (fed a basal diet) and ARG groups (with 1 % ARG added). In the ARG group, backfat thickness, shear force in the longissimus thoracis (LT) muscle, and C16:0 and SFA contents in the subcutaneous adipose tissue (SAT) were reduced, whereas the eye muscle area, a* value, and intramuscular fat, C18:2n-6c, C20:4n-6, C20:5n-3, and PUFA contents in the LT were elevated. Moreover, the ARG group exhibited higher levels of Prevotella, Akkermansia, Faecalibacterium, SCFAs, and GLP-1 in the colon, and lower serum triglyceride and glucose levels. Interestingly, ARG differentially regulated lipid metabolism in the SAT and LT via the GLP-1R/AMPK and triglyceride metabolism signalling pathways. Overall, ARG addition may optimise gut microbiota composition, fat deposition, and meat quality, providing application guidance for regulating fat deposition in lambs.
精氨酸（ARG）可改善肉质和脂肪沉积；然而，其对羔羊肠道微生物群介导的脂质代谢的影响尚不清楚。将24只羔羊分为对照组（饲喂基础日粮）和ARG组（添加1% ARG）。在ARG组中，背膘厚度、胸最长肌（LT）的剪切力以及皮下脂肪组织（SAT）中的C16:0和饱和脂肪酸（SFA）含量降低，而眼肌面积、a*值以及LT中的肌内脂肪、C18:2n-6c、C20:4n-6、C20:5n-3和多不饱和脂肪酸（PUFA）含量升高。此外，ARG组结肠中的普雷沃氏菌、阿克曼氏菌、粪杆菌、短链脂肪酸（SCFAs）和胰高血糖素样肽-1（GLP-1）水平较高，血清甘油三酯和葡萄糖水平较低。有趣的是，ARG通过GLP-1R/AMPK和甘油三酯代谢信号通路对SAT和LT中的脂质代谢进行差异调节。总体而言，添加ARG可能会优化肠道微生物群组成、脂肪沉积和肉质，为调节羔羊脂肪沉积提供应用指导。
