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本文引用的文献

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Mid-life physical activity and calcification of coronary arteries, aorta, and cardiac valves in late life: The Atherosclerosis Risk in Communities (ARIC) study.中年时期的身体活动与晚年冠状动脉、主动脉及心脏瓣膜钙化：社区动脉粥样硬化风险（ARIC）研究
Atherosclerosis. 2025 Mar;402:119115. doi: 10.1016/j.atherosclerosis.2025.119115. Epub 2025 Jan 29.
2
Potential Therapeutic Drug Targets for Hypertension Identified Using Proteomics and Mendelian Randomization.利用蛋白质组学和孟德尔随机化确定的高血压潜在治疗药物靶点
Am J Hypertens. 2025 Sep 16;38(10):841-851. doi: 10.1093/ajh/hpaf011.
3
Recent advancements in targeting the immune system to treat hypertension.靶向免疫系统治疗高血压的最新进展。
Eur J Pharmacol. 2024 Nov 15;983:177008. doi: 10.1016/j.ejphar.2024.177008. Epub 2024 Sep 18.
4
Advances in Understanding of the Role of Immune Cell Phenotypes in Hypertension and Associated Vascular Disease.免疫细胞表型在高血压及相关血管疾病中的作用的认识进展
Can J Cardiol. 2024 Dec;40(12):2321-2339. doi: 10.1016/j.cjca.2024.08.270. Epub 2024 Aug 21.
5
Genome-wide association studies highlight novel risk loci for septal defects and left-sided congenital heart defects.全基因组关联研究强调了隔膜缺陷和左侧先天性心脏缺陷的新风险位点。
BMC Genomics. 2024 Mar 7;25(1):256. doi: 10.1186/s12864-024-10172-x.
6
Mitochondria in endothelial cells angiogenesis and function: current understanding and future perspectives.内皮细胞血管生成和功能中的线粒体：当前的认识和未来展望。
J Transl Med. 2023 Jul 5;21(1):441. doi: 10.1186/s12967-023-04286-1.
7
The therapeutic concordance approach reduces adverse drug reactions in patients with resistant hypertension.治疗一致性方法可减少顽固性高血压患者的药物不良反应。
Front Cardiovasc Med. 2023 May 5;10:1137706. doi: 10.3389/fcvm.2023.1137706. eCollection 2023.
8
Role of inflammation, immunity, and oxidative stress in hypertension: New insights and potential therapeutic targets.炎症、免疫和氧化应激在高血压中的作用：新的见解和潜在的治疗靶点。
Front Immunol. 2023 Jan 10;13:1098725. doi: 10.3389/fimmu.2022.1098725. eCollection 2022.
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The selective aldosterone synthase inhibitor Baxdrostat significantly lowers blood pressure in patients with resistant hypertension.选择性醛固酮合酶抑制剂巴多司他可显著降低顽固性高血压患者的血压。
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The emerging multifunctional roles of ERAP1, ERAP2 and IRAP between antigen processing and renin-angiotensin system modulation.内质网氨肽酶 1（ERAP1）、内质网氨肽酶 2（ERAP2）和免疫相关氨肽酶（IRAP）在抗原加工和肾素-血管紧张素系统调节之间新兴的多功能作用。
Front Immunol. 2022 Sep 20;13:1002375. doi: 10.3389/fimmu.2022.1002375. eCollection 2022.

Integrating Proteomics and Mendelian Randomization to Identify New Therapeutic Targets.

作者信息

Santulli Gaetano, Varzideh Fahimeh, Kansakar Urna, Jankauskas Stanislovas S, Wilson Scott, Mone Pasquale

机构信息

Department of Medicine, Division of Cardiology, Wilf Family Cardiovascular Research Institute, Einstein - Mount Sinai Diabetes Research Center (ES-DRC), Einstein Institute for Neuroimmunology and Inflammation (INI), Albert Einstein College of Medicine, New York, NY, USA.

Department of Molecular Pharmacology, Einstein Institute for Aging Research, Fleischer Institute for Diabetes and Metabolism (FIDAM), Albert Einstein College of Medicine, New York, NY, USA.

出版信息

Am J Hypertens. 2025 Mar 14. doi: 10.1093/ajh/hpaf034.

DOI:10.1093/ajh/hpaf034
PMID:40083258
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12424538/
Abstract
摘要