DiRuggiero Douglas, DiRuggiero Margaret
Dr. DiRuggiero is with the Skin Cancer and Cosmetic Dermatology Center in Rome, Georgia.
Ms. DiRuggiero is with Emory University School of Medicine in Atlanta, Georgia.
J Clin Aesthet Dermatol. 2025 Jan-Feb;18(1-2 Suppl 1):S16-S20.
Corticosteroids are widely prescribed for a variety of dermatologic indications. However, since 2020, regulatory bodies from Canada and the United Kingdom, as well as academic and patient advocacy societies, are increasingly calling for limiting topical corticosteroid use due to safety concerns. This article reviews the variety and extent of both cutaneous adverse effects (i.e., steroid-induced damage) and systemic adverse effects from topical corticosteroids and explores alternative therapies. The risk of adverse effects increases with steroid potency, amount, duration, and frequency of use across indications, routes of administration, and prescribers (i.e., cumulative steroid dose). In order to reduce these safety risks, clinicians should prescribe steroids appropriately and counsel patients on appropriate use and consider combination topical corticosteroid therapy or newer alternative steroid-sparing treatments.
皮质类固醇被广泛用于多种皮肤科适应症。然而，自2020年以来，加拿大和英国的监管机构以及学术和患者倡导团体，由于安全问题，越来越呼吁限制局部使用皮质类固醇。本文回顾了局部皮质类固醇的皮肤不良反应（即类固醇诱导的损伤）和全身不良反应的种类及程度，并探讨了替代疗法。不良反应的风险会随着类固醇的效力、用量、持续时间以及在不同适应症、给药途径和处方者中的使用频率（即累积类固醇剂量）而增加。为了降低这些安全风险，临床医生应合理开具类固醇药物，并就正确使用方法向患者提供咨询，同时考虑联合局部皮质类固醇治疗或更新的替代类固醇节省疗法。
