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本文引用的文献

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How We Do It: Subcutaneous Sodium Deoxycholate Injections With or Without Triamcinolone for Reduction of Submental Fat.
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3
Efficacy and Safety of ATX-101 by Treatment Session: Pooled Analysis of Data From the Phase 3 REFINE Trials.按治疗疗程分析ATX-101的疗效和安全性：3期REFINE试验数据的汇总分析
Aesthet Surg J. 2018 Aug 16;38(9):998-1010. doi: 10.1093/asj/sjy008.
4
Submental-Cervical Angle: Perceived Attractiveness and Threshold Values of Desire for Surgery.颏下-颈部角度：感知到的吸引力及手术意愿阈值
J Maxillofac Oral Surg. 2016 Dec;15(4):469-477. doi: 10.1007/s12663-015-0872-4. Epub 2015 Dec 11.
5
Prevention and Management of Injection-Related Adverse Effects in Facial Aesthetics: Considerations for ATX-101 (Deoxycholic Acid Injection) Treatment.面部美学中注射相关不良反应的预防与管理：ATX-101（脱氧胆酸注射液）治疗的考量因素
Dermatol Surg. 2016 Nov;42 Suppl 1:S300-S304. doi: 10.1097/DSS.0000000000000898.
6
Management of Patient Experience With ATX-101 (Deoxycholic Acid Injection) for Reduction of Submental Fat.ATX-101（脱氧胆酸注射液）治疗颏下脂肪减少患者体验的管理
Dermatol Surg. 2016 Nov;42 Suppl 1:S288-S299. doi: 10.1097/DSS.0000000000000908.
7
Overview of ATX-101 (Deoxycholic Acid Injection): A Nonsurgical Approach for Reduction of Submental Fat.ATX-101（脱氧胆酸注射液）概述：一种减少颏下脂肪的非手术方法。
Dermatol Surg. 2016 Nov;42 Suppl 1:S263-S270. doi: 10.1097/DSS.0000000000000870.
8
ATX-101 for reduction of submental fat: A phase III randomized controlled trial.ATX-101 用于减少颏下脂肪：一项 III 期随机对照试验。
J Am Acad Dermatol. 2016 Oct;75(4):788-797.e7. doi: 10.1016/j.jaad.2016.04.028. Epub 2016 Jul 16.
9
REFINE-1, a Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase 3 Trial With ATX-101, an Injectable Drug for Submental Fat Reduction.REFINE-1，一项多中心、随机、双盲、安慰剂对照的3期试验，使用ATX-101（一种用于减少颏下脂肪的注射药物）。
Dermatol Surg. 2016 Jan;42(1):38-49. doi: 10.1097/DSS.0000000000000578.
10
Validated composite assessment scales for the global face.全球面部的验证性综合评估量表。
Dermatol Surg. 2012 Feb;38(2 Spec No.):294-308. doi: 10.1111/j.1524-4725.2011.02252.x.

添加低剂量利多卡因和曲安奈德可减少2-脱氧胆酸盐注射的不良反应，且不影响长期效果。

The Addition of Low-Dose Lidocaine and Triamcinolone Reduces the Adverse Effects of 2-Deoxycholate Injection Without Affecting the Long-Term Results.

作者信息

Ge Shealinna, Weiss Robert A, Schilling Laura, Noell Claire M

机构信息

Maryland Laser Skin & Vein Institute, Hunt Valley, Maryland, USA.

Aesthetic Dermatology Associates, Paoli, Pennsylvania, USA.

出版信息

J Cosmet Dermatol. 2025 Mar;24(3):e70072. doi: 10.1111/jocd.70072.

DOI:10.1111/jocd.70072
PMID:40084635
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11907679/
Abstract

INTRODUCTION

The study investigates the efficacy of combining low-dose triamcinolone acetonide (TAC) and lidocaine with deoxycholic acid (DCA) injections to reduce adverse effects (AEs) without compromising long-term results.

METHODS

A double-blind, randomized trial was conducted with 15 subjects, divided into a control group (DCA with lidocaine) and an intervention group (DCA with low-dose TAC and lidocaine). The primary outcomes measured were injection pain, swelling, and submental fat reduction.

RESULTS

Results indicated that the intervention group experienced significantly reduced pain and swelling compared to the control group. Both groups showed similar efficacy in submental fat reduction, with the intervention group demonstrating a greater mean volumetric loss.

CONCLUSION

The study concludes that the addition of low-dose TAC and lidocaine to DCA injections is a safe and effective method to enhance patient comfort and treatment outcomes without inducing steroid-related side effects.

摘要

引言

本研究调查了低剂量曲安奈德（TAC）和利多卡因与脱氧胆酸（DCA）联合注射在不影响长期效果的情况下减少不良反应（AE）的疗效。

方法

对15名受试者进行了一项双盲随机试验，分为对照组（DCA加利多卡因）和干预组（DCA加低剂量TAC和利多卡因）。测量的主要结果是注射疼痛、肿胀和颏下脂肪减少。

结果

结果表明，与对照组相比，干预组的疼痛和肿胀明显减轻。两组在颏下脂肪减少方面显示出相似的疗效，干预组的平均体积损失更大。

结论

该研究得出结论，在DCA注射中添加低剂量TAC和利多卡因是一种安全有效的方法，可以提高患者的舒适度和治疗效果，而不会引起类固醇相关的副作用。