Guo Li, Fu Ziming, Li Haoran, Wei Ruibo, Guo Jing, Wang Haiwang, Qi Jian
Key Laboratory of Dielectric and Electrolyte Functional Material Hebei Province, Northeastern University at Qinhuangdao, Qinhuangdao 066004, China.
Key Laboratory of Dielectric and Electrolyte Functional Material Hebei Province, Northeastern University at Qinhuangdao, Qinhuangdao 066004, China.
Adv Colloid Interface Sci. 2025 Jun;340:103470. doi: 10.1016/j.cis.2025.103470. Epub 2025 Mar 7.
Cancer is a significant contributor to mortality worldwide, posing a significant threat to human life and health. The unique bioactivity, ability to precisely control drug release, and minimally invasive properties of hydrogels are indispensable attributes that facilitate optimal performance in cancer therapy. However, conventional hydrogels lack the ability to dynamically respond to changes in the surrounding environment, withstand drastic changes in the microenvironment, and trigger drug release on demand. Therefore, this review focuses on smart-responsive hydrogels that are capable of adapting and responding to external stimuli. We comprehensively summarize the raw materials, preparation, and cross-linking mechanisms of smart hydrogels derived from natural and synthetic materials, elucidate the response principles of various smart-responsive hydrogels according to different stimulation sources. Further, we systematically illustrate the important role played by hydrogels in modern cancer therapies within the context of therapeutic principles. Meanwhile, the smart hydrogel that uses machine learning to design precise drug delivery has shown great prospects in cancer therapy. Finally, we present the outlook on future developments and make suggestions for future related work. It is anticipated that this review will promote the practical application of smart hydrogels in cancer therapy and contribute to the advancement of medical treatment.
癌症是全球死亡率的一个重要因素，对人类生命和健康构成重大威胁。水凝胶独特的生物活性、精确控制药物释放的能力以及微创特性是在癌症治疗中实现最佳性能不可或缺的属性。然而，传统水凝胶缺乏动态响应周围环境变化、承受微环境剧烈变化以及按需触发药物释放的能力。因此，本综述聚焦于能够适应和响应外部刺激的智能响应水凝胶。我们全面总结了天然和合成材料衍生的智能水凝胶的原材料、制备方法和交联机制，根据不同的刺激源阐明了各种智能响应水凝胶的响应原理。此外，我们在治疗原理的背景下系统地阐述了水凝胶在现代癌症治疗中所起的重要作用。同时，利用机器学习设计精确药物递送的智能水凝胶在癌症治疗中已显示出巨大前景。最后，我们展望了未来的发展并对未来相关工作提出建议。预计本综述将促进智能水凝胶在癌症治疗中的实际应用，并推动医学治疗的进步。
