Saikeaw Tanasit, Tipmanee Phadungkiat, Chareonpornwattana Pasut, Watthanasathitarpha Gritcharat, Dasom Kanyanat, Limvorapitak Thitithep
Colorectal Division, Department of Surgery, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Colorectal Division, Department of Surgery, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Surg Oncol. 2025 Apr;59:102203. doi: 10.1016/j.suronc.2025.102203. Epub 2025 Mar 6.
Tumor deposits (TD) have been shown to have prognostic implications in patients diagnosed with colorectal cancer (CRC), although their impact appears to be modest compared to regional lymph node metastases.
A retrospective analysis was conducted involving patients with colorectal cancer in stages I-III who underwent curative resections between January 2015 and December 2019 in the tertiary care center in Thailand. These patients were divided into two cohorts: TD positive and TD negative. Additionally, the patients were subsequently classified into N0, N1, and N2 groups. Disease-free survival and overall survival were compared.
Among the 1015 eligible patients, 176 (17.3 %) had tumor deposits (TD), while 374 patients (36.8 %) had positive lymph nodes (LN). The TD positive group demonstrated a significantly lower 5-year overall survival rate (OS) and 5-year disease-free survival rate (DFS) compared to the TD negative group (73.5 % vs 85.9 %, p < 0.001 and 72.5 % vs 87.9 %, p < 0.001 respectively). Upon stratification by various N stages, the presence of TD was notably associated with DFS in the N1 group (5-year DFS: 84.3 % vs. 89.2 %, p = 0.006). Multivariate logistic analyses shown TD as an independent predictor of disease recurrence [p = 0.02; hazard ratio (HR):1.71 (1.11-2.64)].
The presence of TD was significantly correlated with reduced overall survival (OS) and disease-free survival (DFS) in colorectal cancer, especially in patients with nodal metastases.
肿瘤沉积物（TD）已被证明对诊断为结直肠癌（CRC）的患者具有预后意义，尽管与区域淋巴结转移相比，其影响似乎较小。
对2015年1月至2019年12月在泰国三级医疗中心接受根治性切除的I - III期结直肠癌患者进行回顾性分析。这些患者被分为两个队列：TD阳性和TD阴性。此外，患者随后被分为N0、N1和N2组。比较无病生存期和总生存期。
在1015例符合条件的患者中，176例（17.3%）有肿瘤沉积物（TD），而374例患者（36.8%）有阳性淋巴结（LN）。与TD阴性组相比，TD阳性组的5年总生存率（OS）和5年无病生存率（DFS）显著更低（分别为73.5%对85.9%，p < 0.001和72.5%对87.9%，p < 0.001）。在按不同N分期分层后，TD的存在与N1组的DFS显著相关（5年DFS：84.3%对89.2%，p = 0.006）。多因素逻辑分析显示TD是疾病复发的独立预测因素[p = 0.02；危险比（HR）：1.71（1.11 - 2.64）]。
TD的存在与结直肠癌患者的总生存期（OS）和无病生存期（DFS）降低显著相关，尤其是在有淋巴结转移的患者中。
