Landgren Anton J, Bilberg Annelie, Eliasson Björn, Torres Linda, Dehlin Mats, Jacobsson Lennart T H, Larsson Ingrid, Klingberg Eva
Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Region Västra Götaland, Research and Development Primary Health Care, Gothenburg, Södra Bohuslän, Sweden.
Adv Rheumatol. 2025 Mar 14;65(1):13. doi: 10.1186/s42358-025-00444-9.
In this interventional weight loss study, health-related quality of life (HRQoL), anxiety, depression and fatigue were compared at baseline (BL) and at 12 months (M12) in patients with psoriatic arthritis (PsA) and controls.
PsA patients (n = 39) between 25 and 75 years of age, with body mass index (BMI) ≥ 33 kg/m were included in a weight loss intervention with very low energy diet (VLED) for 12 or 16 weeks depending on BL BMI < 40 or ≥ 40 kg/m. The 36-item short-form health survey (SF-36) was used to assess HRQoL. Anxiety and depression were assessed by the Hospital Anxiety and Depression Scale. Assessments were done at BL, M3, M6 and M12. As controls (n = 39), obese individuals, already planned for VLED treatment were recruited and matched for sex, age and weight to the PsA patients.
In PsA patients, physical HRQoL, as demonstrated by the physical component summary (PCS) of SF-36, improved from median (IQR) 34 (25-45) at BL to 43 (34-50) at M12, p = 0.009. No significant effect on mental HRQoL, demonstrated by the mental component summary (MCS) score, was seen. Similarly in controls, PCS significantly improved (median IQR, 44 (36-50) at BL to 52 (44-55) at M12, p < 0.001), whereas no significant improvement was seen in MCS. Anxiety and depression decreased significantly in both PsA patients and controls.
The weight loss intervention was associated with significant improvements in physical HRQoL, as well as anxiety and depression, in PsA patients and controls.
ClinicalTrials.gov identifier: NCT02917434, registered on September 21, 2016, retrospectively registered.
在这项干预性减肥研究中，比较了银屑病关节炎（PsA）患者和对照组在基线（BL）及12个月（M12）时的健康相关生活质量（HRQoL）、焦虑、抑郁和疲劳情况。
纳入年龄在25至75岁之间、体重指数（BMI）≥33 kg/m²的PsA患者（n = 39），根据基线BMI<40或≥40 kg/m²，进行为期12周或16周的极低能量饮食（VLED）减肥干预。采用36项简短健康调查问卷（SF - 36）评估HRQoL。通过医院焦虑抑郁量表评估焦虑和抑郁情况。在BL、M3、M6和M12进行评估。作为对照组（n = 39），招募已计划接受VLED治疗的肥胖个体，并在性别、年龄和体重方面与PsA患者进行匹配。
在PsA患者中，SF - 36的身体成分总结（PCS）所显示的身体HRQoL从BL时的中位数（IQR）34（25 - 45）提高到M12时的43（34 - 50），p = 0.009。未观察到对精神成分总结（MCS）评分所显示的精神HRQoL有显著影响。同样，在对照组中，PCS显著改善（中位数IQR，从BL时的44（36 - 50）提高到M12时的52（44 - 55），p < 0.001），而MCS未观察到显著改善。PsA患者和对照组的焦虑和抑郁均显著降低。
减肥干预与PsA患者和对照组的身体HRQoL以及焦虑和抑郁的显著改善相关。
ClinicalTrials.gov标识符：NCT02917434，于2016年9月21日注册，回顾性注册。
