Shime Nobuaki, Nakada Taka-Aki, Yatabe Tomoaki, Yamakawa Kazuma, Aoki Yoshitaka, Inoue Shigeaki, Iba Toshiaki, Ogura Hiroshi, Kawai Yusuke, Kawaguchi Atsushi, Kawasaki Tatsuya, Kondo Yutaka, Sakuraya Masaaki, Taito Shunsuke, Doi Kent, Hashimoto Hideki, Hara Yoshitaka, Fukuda Tatsuma, Matsushima Asako, Egi Moritoki, Kushimoto Shigeki, Oami Takehiko, Kikutani Kazuya, Kotani Yuki, Aikawa Gen, Aoki Makoto, Akatsuka Masayuki, Asai Hideki, Abe Toshikazu, Amemiya Yu, Ishizawa Ryo, Ishihara Tadashi, Ishimaru Tadayoshi, Itosu Yusuke, Inoue Hiroyasu, Imahase Hisashi, Imura Haruki, Iwasaki Naoya, Ushio Noritaka, Uchida Masatoshi, Uchi Michiko, Umegaki Takeshi, Umemura Yutaka, Endo Akira, Oi Marina, Ouchi Akira, Osawa Itsuki, Oshima Yoshiyasu, Ota Kohei, Ohno Takanori, Okada Yohei, Okano Hiromu, Ogawa Yoshihito, Kashiura Masahiro, Kasugai Daisuke, Kano Ken-Ichi, Kamidani Ryo, Kawauchi Akira, Kawakami Sadatoshi, Kawakami Daisuke, Kawamura Yusuke, Kandori Kenji, Kishihara Yuki, Kimura Sho, Kubo Kenji, Kuribara Tomoki, Koami Hiroyuki, Koba Shigeru, Sato Takehito, Sato Ren, Sawada Yusuke, Shida Haruka, Shimada Tadanaga, Shimizu Motohiro, Shimizu Kazushige, Shiraishi Takuto, Shinkai Toru, Tampo Akihito, Sugiura Gaku, Sugimoto Kensuke, Sugimoto Hiroshi, Suhara Tomohiro, Sekino Motohiro, Sonota Kenji, Taito Mahoko, Takahashi Nozomi, Takeshita Jun, Takeda Chikashi, Tatsuno Junko, Tanaka Aiko, Tani Masanori, Tanikawa Atsushi, Chen Hao, Tsuchida Takumi, Tsutsumi Yusuke, Tsunemitsu Takefumi, Deguchi Ryo, Tetsuhara Kenichi, Terayama Takero, Togami Yuki, Totoki Takaaki, Tomoda Yoshinori, Nakao Shunichiro, Nagasawa Hiroki, Nakatani Yasuhisa, Nakanishi Nobuto, Nishioka Norihiro, Nishikimi Mitsuaki, Noguchi Satoko, Nonami Suguru, Nomura Osamu, Hashimoto Katsuhiko, Hatakeyama Junji, Hamai Yasutaka, Hikone Mayu, Hisamune Ryo, Hirose Tomoya, Fuke Ryota, Fujii Ryo, Fujie Naoki, Fujinaga Jun, Fujinami Yoshihisa, Fujiwara Sho, Funakoshi Hiraku, Homma Koichiro, Makino Yuto, Matsuura Hiroshi, Matsuoka Ayaka, Matsuoka Tadashi, Matsumura Yosuke, Mizuno Akito, Miyamoto Sohma, Miyoshi Yukari, Murata Satoshi, Murata Teppei, Yakushiji Hiromasa, Yasuo Shunsuke, Yamada Kohei, Yamada Hiroyuki, Yamamoto Ryo, Yamamoto Ryohei, Yumoto Tetsuya, Yoshida Yuji, Yoshihiro Shodai, Yoshimura Satoshi, Yoshimura Jumpei, Yonekura Hiroshi, Wakabayashi Yuki, Wada Takeshi, Watanabe Shinichi, Ijiri Atsuhiro, Ugata Kei, Uda Shuji, Onodera Ryuta, Takahashi Masaki, Nakajima Satoshi, Honda Junta, Matsumoto Tsuguhiro
Department of Emergency and Critical Care Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Department of Emergency and Critical Care Medicine, Chiba University Graduate School of Medicine, Chiba, Japan.
J Intensive Care. 2025 Mar 14;13(1):15. doi: 10.1186/s40560-025-00776-0.
The 2024 revised edition of the Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock (J-SSCG 2024) is published by the Japanese Society of Intensive Care Medicine and the Japanese Association for Acute Medicine. This is the fourth revision since the first edition was published in 2012. The purpose of the guidelines is to assist healthcare providers in making appropriate decisions in the treatment of sepsis and septic shock, leading to improved patient outcomes. We aimed to create guidelines that are easy to understand and use for physicians who recognize sepsis and provide initial management, specialized physicians who take over the treatment, and multidisciplinary healthcare providers, including nurses, physical therapists, clinical engineers, and pharmacists. The J-SSCG 2024 covers the following nine areas: diagnosis of sepsis and source control, antimicrobial therapy, initial resuscitation, blood purification, disseminated intravascular coagulation, adjunctive therapy, post-intensive care syndrome, patient and family care, and pediatrics. In these areas, we extracted 78 important clinical issues. The GRADE (Grading of Recommendations Assessment, Development and Evaluation) method was adopted for making recommendations, and the modified Delphi method was used to determine recommendations by voting from all committee members. As a result, 42 GRADE-based recommendations, 7 good practice statements, and 22 information-to-background questions were created as responses to clinical questions. We also described 12 future research questions.
日本重症医学会和日本急性医学协会联合发布了《2024年日本脓毒症及脓毒性休克管理临床实践指南》（J-SSCG 2024）修订版。这是自2012年第一版发布以来的第四次修订。本指南旨在帮助医疗服务提供者在脓毒症和脓毒性休克治疗中做出恰当决策，从而改善患者预后。我们的目标是制定出易于被识别脓毒症并提供初始治疗的医生、接手治疗的专科医生以及包括护士、物理治疗师、临床工程师和药剂师在内的多学科医疗服务提供者理解和使用的指南。J-SSCG 2024涵盖以下九个领域：脓毒症诊断与源头控制、抗菌治疗、初始复苏、血液净化、弥散性血管内凝血、辅助治疗、重症监护后综合征、患者及家属护理以及儿科。在这些领域，我们提炼出了78个重要临床问题。指南采用GRADE（推荐分级的评估、制定与评价）方法提出建议，并通过全体委员会成员投票的改良德尔菲法来确定建议。结果，针对临床问题形成了42条基于GRADE的建议、7条良好实践声明以及22条背景信息问题。我们还阐述了12个未来研究问题。
