da Silva Eduardo Alves, Faber Jean, Penitente Arlete Rita, Fernandes Jansen, Bertolucci Paulo Henrique Ferreira, Longo Beatriz Monteiro, Arida Ricardo Mario
Federal University of Sao Paulo - Physiology Department, Brazil.
Federal University of Sao Paulo - Neurology and Neurosurgery Department, Brazil.
Exp Neurol. 2025 Jun;388:115217. doi: 10.1016/j.expneurol.2025.115217. Epub 2025 Mar 13.
Alzheimer's disease (AD) is a neurodegenerative condition that affects memory and cognition, with a higher prevalence in women. Given the lack of effective treatment, physical activity stands out as a complementary approach to prevent or delay disease progression. While numerous studies on humans and animals indicate that aerobic exercise induces brain changes, the impact of resistance exercise (RE) on AD is not fully understood.
This study aimed to investigate the behavioral and molecular changes induced by RE in female transgenic mice with AD at the early and advanced stages of the disease.
Adult (initial phase - 7 to 8 months of age, n = 32) and adult/elderly (advanced phase - 22 to 23 months of age, n = 32) female mice (2xTg-AD) for the APPSWE/PS1dE9 mutation were subjected to a four-week RE protocol. Mobility, anxiety-like behavior, long-term memory (LTM), and depressive-like behavior were assessed. Beta-amyloid (βA) and cytokines were quantified using the ELISA technique.
There was a progressive increase in strength in both trained groups at different ages. RE reversed memory deficits only in adult AD animals and the anxiety-like behavior only in adult/elderly AD animals. RE reversed depressive-like behavior in adult and adult/elderly AD animals. RE reduced βA only in adult AD animals. RE modified the expression of several cytokines in animals in the early and advanced stage of AD.
RE can be a promising strategy to minimize the deleterious effects of AD; however, its effectiveness may be more limited to the early stages of the disease.
阿尔茨海默病（AD）是一种影响记忆和认知的神经退行性疾病，女性患病率更高。鉴于缺乏有效的治疗方法，体育活动作为预防或延缓疾病进展的辅助方法脱颖而出。虽然大量关于人类和动物的研究表明有氧运动可引起大脑变化，但抗阻运动（RE）对AD的影响尚未完全了解。
本研究旨在调查RE对处于疾病早期和晚期的AD雌性转基因小鼠所诱导的行为和分子变化。
对携带APPSWE/PS1dE9突变的成年（初始阶段——7至8月龄，n = 32）和成年/老年（晚期阶段——22至23月龄，n = 32）雌性小鼠（2xTg-AD）进行为期四周的RE方案。评估运动能力、焦虑样行为、长期记忆（LTM）和抑郁样行为。使用ELISA技术对β-淀粉样蛋白（βA）和细胞因子进行定量。
不同年龄的两个训练组力量均逐渐增加。RE仅逆转了成年AD动物的记忆缺陷，仅逆转了成年/老年AD动物的焦虑样行为。RE逆转了成年和成年/老年AD动物的抑郁样行为。RE仅在成年AD动物中降低了βA。RE改变了AD早期和晚期动物中几种细胞因子的表达。
RE可能是一种有前景的策略，可将AD的有害影响降至最低；然而，其有效性可能在疾病早期更为有限。
