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[原发性甲状旁腺功能亢进症合并异位甲状旁腺腺瘤罕见定位的处理]

[Management of primary hyperparathyroidism with rare localization of ectopic adenoma parathyroid gland].

作者信息

Aboisheva E A, Avsievich E S, Korchagina M O, Degtyarev M V, Bibik E E, Beltsevich D G, Pigarova E A, Sheremeta M S

机构信息

Endocrine Research Centre.

出版信息

Probl Endokrinol (Mosk). 2024 Apr 1;71(1):20-26. doi: 10.14341/probl13425.

Abstract

Topical diagnosis can be severely complicated in patients with primary hyperparathyroidism (PHPT) due to the ectopic placement of parathyroid gland (PTG) formations. We report a clinical case of PHPT in an 84-year-old patient caused by ectopic PTG adenoma located behind the right internal jugular vein at the level of the right submandibular gland. The impossibility of surgery for a long time due to the absence of a topical diagnosis has necessitated conservative treatment was required to get the hypercalcemia under control. In view of the concomitant deficiency of vitamin D, an attempt was made to use therapy with saturating doses of cholecalciferol under dynamic monitoring of the indicators of phosphorus-calcium metabolism, which allowed to achieve a significant decrease in PTH levels while maintaining normocalcemia.

摘要

由于甲状旁腺(PTG)结构的异位放置,原发性甲状旁腺功能亢进症(PHPT)患者的局部诊断可能会严重复杂化。我们报告了一例84岁PHPT患者的临床病例,其病因是位于右下颌下腺水平的右颈内静脉后方的异位PTG腺瘤。由于缺乏局部诊断,长期无法进行手术,因此需要采取保守治疗来控制高钙血症。鉴于同时存在维生素D缺乏,我们尝试在磷钙代谢指标的动态监测下使用饱和剂量的胆钙化醇进行治疗,这使得在维持血钙正常的同时,甲状旁腺激素(PTH)水平显著降低。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb22/11931465/ea978e54d3be/problendo-71-13425-g001.jpg

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