施瓦茨曼-戴蒙德综合征患者的淋巴系统恶性肿瘤
Lymphoid malignancies in patients with Shwachman-Diamond syndrome.
作者信息
Reed Helen D, Do Hyunwoo, Weller Edie, Harris Marian H, Reilly Christopher R, Tsai Harrison K, Farrar Jason E, Lau Bonnie W, Pommert Lauren, Gamper Christopher, Atkinson Ian, Coyne Katherine, Joos Margret, Loveless Sara, Steltz Sarah, Cheng Leah, Malsch Maggie, Myers Kasiani, Shimamura Akiko
机构信息
Dana-Farber and Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, MA.
Biostatistics and Research Design Center, Boston Children's Hospital, Boston, MA.
出版信息
Blood. 2025 May 22;145(21):2528-2532. doi: 10.1182/blood.2024026507.
This study identified an increased risk of lymphoid malignancy in Shwachman-Diamond syndrome (SDS) with an observed risk 38-fold higher than expected based on population data. Increased toxicity was observed with standard therapies in patients with SDS.
本研究发现，施瓦茨曼-戴蒙德综合征（SDS）患者发生淋巴系统恶性肿瘤的风险增加，根据人群数据观察到的风险比预期高38倍。在SDS患者中，标准疗法观察到毒性增加。
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