A long journey to the discovery of nuclear receptor coactivator existence, physiology, pathology, and therapy.
作者信息
O'Malley Bert W
出版信息
J Biol Chem. 2025 May;301(5):108415. doi: 10.1016/j.jbc.2025.108415. Epub 2025 Mar 14.
Abstract
摘要
相似文献
1
A long journey to the discovery of nuclear receptor coactivator existence, physiology, pathology, and therapy.发现核受体共激活因子的存在、生理学、病理学及治疗方法的漫长历程。
J Biol Chem. 2025 May;301(5):108415. doi: 10.1016/j.jbc.2025.108415. Epub 2025 Mar 14.
2
Three amino acids specify coactivator choice by retinoid X receptors.三种氨基酸决定视黄酸X受体对共激活因子的选择。
Mol Endocrinol. 2000 Aug;14(8):1198-209. doi: 10.1210/mend.14.8.0495.
3
SRC-3 has a role in cancer other than as a nuclear receptor coactivator.SRC-3 在癌症中的作用不仅是作为核受体共激活剂。
Int J Biol Sci. 2011;7(5):664-72. doi: 10.7150/ijbs.7.664. Epub 2011 May 24.
4
Knockdown of NCOA2 Inhibits the Growth and Progression of Gastric Cancer by Affecting the Wnt Signaling Pathway-Related Protein Expression.敲低 NCOA2 通过影响 Wnt 信号通路相关蛋白表达抑制胃癌的生长和进展。
Technol Cancer Res Treat. 2020 Jan-Dec;19:1533033820928072. doi: 10.1177/1533033820928072.
5
Transcription coactivator PRIP, the peroxisome proliferator-activated receptor (PPAR)-interacting protein, is redundant for the function of nuclear receptors PParalpha and CAR, the constitutive androstane receptor, in mouse liver.转录共激活因子PRIP，即过氧化物酶体增殖物激活受体（PPAR）相互作用蛋白，对小鼠肝脏中核受体过氧化物酶体增殖物激活受体α（PParalpha）和组成型雄甾烷受体（CAR）的功能来说是多余的。
Gene Expr. 2007;13(4-5):255-69. doi: 10.3727/000000006780666948.
6
A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA.RNA结合DEAD盒蛋白的一个亚家族通过与RNA共激活因子SRA的N端激活域（AF-1）作为雌激素受体α共激活因子发挥作用。
EMBO J. 2001 Mar 15;20(6):1341-52. doi: 10.1093/emboj/20.6.1341.
7
Transcriptional regulation of steroid receptor coactivator-1 (SRC-1) in glucocorticoid action.糖皮质激素作用中类固醇受体辅激活因子-1（SRC-1）的转录调控
Endocr Res. 2000 Nov;26(4):1033-8. doi: 10.3109/07435800009048635.
8
Multiple signal input and output domains of the 160-kilodalton nuclear receptor coactivator proteins.160千道尔顿核受体辅激活蛋白的多个信号输入和输出结构域。
Mol Cell Biol. 1999 Sep;19(9):6164-73. doi: 10.1128/MCB.19.9.6164.
9
Expression of estrogen receptor coactivators in the rat uterus.雌激素受体共激活因子在大鼠子宫中的表达。
Biol Reprod. 2000 Aug;63(2):361-7. doi: 10.1095/biolreprod63.2.361.
10
A structural mechanism of nuclear receptor biased agonism.核受体偏倚激动剂的结构机制。
Proc Natl Acad Sci U S A. 2022 Dec 13;119(50):e2215333119. doi: 10.1073/pnas.2215333119. Epub 2022 Dec 5.
本文引用的文献
1
Steroid receptor coactivator 3 is a key modulator of regulatory T cell-mediated tumor evasion.类固醇受体共激活因子 3 是调节性 T 细胞介导的肿瘤逃逸的关键调节因子。
Proc Natl Acad Sci U S A. 2023 Jun 6;120(23):e2221707120. doi: 10.1073/pnas.2221707120. Epub 2023 May 30.
2
Steroid receptor coactivators - their role in immunity.甾体激素受体共激活因子——其在免疫中的作用。
Front Immunol. 2022 Dec 13;13:1079011. doi: 10.3389/fimmu.2022.1079011. eCollection 2022.
3
A steroid receptor coactivator small molecule "stimulator" attenuates post-stroke ischemic brain injury.一种类固醇受体共激活因子小分子“刺激剂”可减轻中风后缺血性脑损伤。
Front Mol Neurosci. 2022 Dec 1;15:1055295. doi: 10.3389/fnmol.2022.1055295. eCollection 2022.
4
Spatial definition of the human progesterone receptor-B transcriptional complex.人孕激素受体-B转录复合物的空间定义
iScience. 2022 Oct 10;25(11):105321. doi: 10.1016/j.isci.2022.105321. eCollection 2022 Nov 18.
5
Steroid receptor coactivator-3 inhibition generates breast cancer antitumor immune microenvironment.抑制类固醇受体共激活因子-3 可产生乳腺癌抗肿瘤免疫微环境。
Breast Cancer Res. 2022 Oct 31;24(1):73. doi: 10.1186/s13058-022-01568-2.
6
Steroid receptor coactivator 3 (SRC-3/AIB1) is enriched and functional in mouse and human Tregs.类固醇受体共激活因子 3（SRC-3/AIB1）在小鼠和人类 Tregs 中丰富且具有功能。
Sci Rep. 2021 Feb 9;11(1):3441. doi: 10.1038/s41598-021-82945-3.
7
A steroid receptor coactivator stimulator (MCB-613) attenuates adverse remodeling after myocardial infarction.一种类固醇受体共激活剂刺激剂（MCB-613）可减轻心肌梗死后的不良重构。
Proc Natl Acad Sci U S A. 2020 Dec 8;117(49):31353-31364. doi: 10.1073/pnas.2011614117. Epub 2020 Nov 23.
8
Structural Insights of Transcriptionally Active, Full-Length Androgen Receptor Coactivator Complexes.转录活性全长雄激素受体共激活因子复合物的结构见解
Mol Cell. 2020 Sep 3;79(5):812-823.e4. doi: 10.1016/j.molcel.2020.06.031. Epub 2020 Jul 14.
9
SRC-3 inhibition blocks tumor growth of pancreatic ductal adenocarcinoma. SRC-3 抑制可阻断胰腺导管腺癌的肿瘤生长。
Cancer Lett. 2019 Feb 1;442:310-319. doi: 10.1016/j.canlet.2018.11.012. Epub 2018 Nov 10.
10
Structural and Functional Impacts of ER Coactivator Sequential Recruitment.内质网共激活因子顺序招募的结构和功能影响
Mol Cell. 2017 Sep 7;67(5):733-743.e4. doi: 10.1016/j.molcel.2017.07.026. Epub 2017 Aug 24.
Zotero 插件