Bahya Aqeel M, Abid Mushriq F, Aljohani Khalid A, Porntaveetus Thantrira
Orthodontic Department, College of Dentistry/ University of Babylon, Babylon, Iraq.
Orthodontic Department, College of Dentistry/ University of Baghdad, Baghdad, Iraq.
J Taibah Univ Med Sci. 2025 Feb 24;20(1):112-119. doi: 10.1016/j.jtumed.2025.01.004. eCollection 2025 Feb.
The aim of the present study was to assess the association between class III malocclusion and genetic polymorphisms in two genes: (rs4434184) and (rs881301).
A total of 60 patients, 30 with skeletal class I and 30 with skeletal class III malocclusion, were included in this study. Salivary DNA samples were collected and analyzed with Sanger sequencing. Digital tracing was performed on lateral cephalometric radiographs loaded into AutoCAD software (Version 2017) to assess the anteroposterior and vertical relationships of the maxillary and mandibular arches. Genotype distribution was compared between groups with the chi-square test to assess Hardy-Weinberg equilibrium. Multiple logistic regression analysis was conducted.
The rs4434184 polymorphism was associated with longer mandibular length. In contrast, shorter maxillary length, longer mandibular length, and hypodivergent face were correlated with the rs881301 polymorphism in New polymorphisms, including rs881300, rs881299, and rs7829058, have been identified in association with various phenotypes. Notably, rs881300 and rs7829058 displayed a substantial association with skeletal class III, whereas rs881299 revealed a significant association with a hypodivergent face and longer mandibular anteroposterior length.
A potential association was observed between class III skeletal malocclusion-related traits and polymorphisms of (rs4434184) and (rs881301, rs881300, rs881299, and rs7829058). This finding holds promise for enhancing skeletal prediction and informing orthodontic treatment planning.
本研究旨在评估Ⅲ类错牙合与两个基因（rs4434184和rs881301）的基因多态性之间的关联。
本研究共纳入60例患者，其中30例为骨骼Ⅰ类错牙合患者，30例为骨骼Ⅲ类错牙合患者。收集唾液DNA样本并采用桑格测序法进行分析。对导入AutoCAD软件（2017版）的头颅侧位片进行数字描记，以评估上颌和下颌牙弓的前后关系及垂直关系。采用卡方检验比较组间基因型分布，以评估哈迪-温伯格平衡。进行多因素逻辑回归分析。
rs4434184多态性与下颌长度较长有关。相比之下，上颌长度较短、下颌长度较长和面部低角型与rs881301多态性相关。已鉴定出与各种表型相关的新的多态性，包括rs881300、rs881299和rs7829058。值得注意的是，rs881300和rs7829058与骨骼Ⅲ类错牙合有显著关联，而rs881299与面部低角型和下颌前后长度较长有显著关联。
观察到Ⅲ类骨骼错牙合相关特征与（rs4434184）和（rs881301、rs881300、rs881299和rs7829058）的多态性之间存在潜在关联。这一发现有望增强骨骼预测能力并为正畸治疗计划提供参考。
