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超越视觉:光对生物钟及情绪相关行为的影响

Beyond vision: effects of light on the circadian clock and mood-related behaviours.

作者信息

Stewart Dean, Albrecht Urs

机构信息

Department of Biology, University of Fribourg, Fribourg, Switzerland.

出版信息

NPJ Biol Timing Sleep. 2025;2(1):12. doi: 10.1038/s44323-025-00029-1. Epub 2025 Mar 13.

DOI:10.1038/s44323-025-00029-1
PMID:40092590
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11906358/
Abstract

Light is a crucial environmental factor that influences various aspects of life, including physiological and psychological processes. While light is well-known for its role in enabling humans and other animals to perceive their surroundings, its influence extends beyond vision. Importantly, light affects our internal time-keeping system, the circadian clock, which regulates daily rhythms of biochemical and physiological processes, ultimately impacting mood and behaviour. The 24-h availability of light can have profound effects on our well-being, both physically and mentally, as seen in cases of jet lag and shift work. This review summarizes the intricate relationships between light, the circadian clock, and mood-related behaviours, exploring the underlying mechanisms and its implications for health.

摘要

光作为一种关键的环境因素,影响着生命的各个方面,包括生理和心理过程。尽管光在使人类和其他动物感知周围环境方面的作用广为人知,但其影响却不止于视觉。重要的是,光会影响我们的内部计时系统——生物钟,该生物钟调节着生化和生理过程的日常节律,最终影响情绪和行为。正如在时差反应和轮班工作的案例中所见,24小时的光照条件对我们的身心健康会产生深远影响。本综述总结了光、生物钟和情绪相关行为之间的复杂关系,探讨了其潜在机制及其对健康的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b83f/11906358/e58311e5d687/44323_2025_29_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b83f/11906358/9783176e66c8/44323_2025_29_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b83f/11906358/975694f2c1bd/44323_2025_29_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b83f/11906358/7fee0e6b3add/44323_2025_29_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b83f/11906358/d3fcfb978ac8/44323_2025_29_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b83f/11906358/e58311e5d687/44323_2025_29_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b83f/11906358/9783176e66c8/44323_2025_29_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b83f/11906358/975694f2c1bd/44323_2025_29_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b83f/11906358/7fee0e6b3add/44323_2025_29_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b83f/11906358/d3fcfb978ac8/44323_2025_29_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b83f/11906358/e58311e5d687/44323_2025_29_Fig5_HTML.jpg

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Prefrontal cortex molecular clock modulates development of depression-like phenotype and rapid antidepressant response in mice.前额皮质分子钟调节小鼠抑郁样表型的发展和快速抗抑郁反应。
Nat Commun. 2024 Aug 23;15(1):7257. doi: 10.1038/s41467-024-51716-9.
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Commun Biol. 2024 Aug 15;7(1):998. doi: 10.1038/s42003-024-06647-y.
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Transcriptomic Plasticity of the Circadian Clock in Response to Photoperiod: A Study in Male Melatonin-Competent Mice.光周期对生物钟转录组可塑性的影响:雄性褪黑素敏感型小鼠的研究。
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Adaptation to photoperiod via dynamic neurotransmitter segregation.通过动态神经递质分隔适应光周期。
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Prefrontal cortex neurons encode ambient light intensity differentially across regions and layers.前额皮质神经元在不同区域和层次上对环境光强度进行有差异的编码。
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