Sayle B A, Fawcett H D, Wilkey D J, Cierny G, Mader J T
J Nucl Med. 1985 Jul;26(7):718-21.
Thirty-three patients with painful joint prostheses and a suspicion of infection were imaged with [111In]chloride. A final diagnosis was established by culture in 19. Of these, 12 were categorized as true positives and three as true negatives. There were two false-positive studies, occurring in patients with knee prostheses. In both, the culture was obtained by aspiration. Two false negatives were in patients with hip prostheses, one of whom had been on long-term antibiotic suppressive therapy. The sensitivity was 86%, specificity 60%, and accuracy 79%. Seventeen of the proven cases had bone imaging prior to [111In]chloride imaging. All 17 static images were positive and were not helpful in differentiating loosening from infection. Using increased uptake on the blood-pool image as a criteria for infection, the sensitivity was 89%, but the specificity was 0. Adding flow studies made little difference in interpreting the blood-pool images. This study shows that [111In]chloride accurate in evaluating infection in prosthesis than bone imaging.
33例关节假体疼痛且怀疑感染的患者接受了氯化铟[111In]显像。最终诊断通过培养确定，其中19例确诊。在这些确诊病例中，12例为真阳性，3例为真阴性。有2例假阳性研究，均发生在膝关节假体患者中。这两例中，培养均通过抽吸获得。2例假阴性发生在髋关节假体患者中，其中1例曾接受长期抗生素抑制治疗。敏感性为86%，特异性为60%，准确性为79%。17例确诊病例在氯化铟[111In]显像之前进行了骨显像。所有17例静态图像均为阳性，对区分松动与感染没有帮助。以血池图像上摄取增加作为感染标准，敏感性为89%，但特异性为0。增加血流研究对血池图像的解读影响不大。这项研究表明，氯化铟[111In]在评估假体感染方面比骨显像更准确。
