Sachan D S, Ruark R A
J Nutr. 1985 Jul;115(7):865-71. doi: 10.1093/jn/115.7.865.
Distribution of carnitine and acylcarnitine in lumen flush and tissue of the small intestine was examined in four groups of male Sprague-Dawley rats fed either a nonpurified diet (groups 1, 2) or the same supplemented with 1% DL-carnitine (groups 3, 4). One group of animals under each dietary regimen (groups 2, 4) was fasted for 24 h prior to killing. Carnitine and acylcarnitines were present in higher concentrations in tissue of the small intestine than in the lumen flush. Even though the diets contained only traces of acid-soluble acylcarnitine, it was present in high concentrations both in tissue of the small intestine and lumen flush. Proximal segments of small intestine tended to concentrate carnitine and acylcarnitines under all conditions of treatment. Carnitine supplementation increased the amounts of carnitines in tissue; however, there was only a minor alteration in the pattern of distribution of carnitine and acylcarnitines.
在四组雄性斯普拉格-道利大鼠中检测了肉碱和酰基肉碱在小肠肠腔冲洗液和组织中的分布情况。这四组大鼠分别喂食非纯化饮食（第1、2组）或添加1% DL-肉碱的相同饮食（第3、4组）。每组饮食方案下的一组动物（第2、4组）在处死前禁食24小时。小肠组织中的肉碱和酰基肉碱浓度高于肠腔冲洗液中的浓度。尽管饮食中仅含有痕量的酸溶性酰基肉碱，但它在小肠组织和肠腔冲洗液中均以高浓度存在。在所有处理条件下，小肠近端段倾向于富集肉碱和酰基肉碱。补充肉碱增加了组织中肉碱的含量；然而，肉碱和酰基肉碱的分布模式仅有轻微改变。
