Mimura Tatsuya, Noma Hidetaka
Department of Ophthalmology, Teikyo University School of Medicine, Tokyo, Japan.
Department of Ophthalmology, Tsurumi University School of Dental Medicine, Tsurumi-ku, Yokohama, Kanagawa, Japan.
Am J Ophthalmol Case Rep. 2025 Feb 18;38:102283. doi: 10.1016/j.ajoc.2025.102283. eCollection 2025 Jun.
Large amounts of v are contained in and paint materials. The inhalation of causes a variety of adverse e report our findings in a rare case of bilateral cystoid macular edema (CME) associated with retinal vein occlusion (RVO) that was exacerbated after painting work.
A 60-year-old male house painter with bilateral RVO developed a persistent CME. He was treated with triamcinolone acetonide and anti-VEGF intravitreal injections, and later with vitrectomy combined with cataract surgery in both eyes due to a persistent bilateral CME. The CME was partially resolved but the CME recurred immediately after beginning his painting work. Urinary metabolites of paint-related VOCs such as 3-methylhippurate, mandelate, and phenylglyoxylate were very high, with an increase of 2700-7000 % compared with normal values. After resigning from the paint job, the patient's CME improved in both eyes.
A CME be exacerbated by the exposure to paint-related VOCs. Our findings suggest that reducing and avoiding the occupational exposure to VOCs and regular measurements of urinary VOC concentration are for those who work in the printing and painting industries.
油漆材料中含有大量挥发性有机化合物（VOCs）。吸入VOCs会导致多种不良反应。我们报告了一例罕见的双侧黄斑囊样水肿（CME）合并视网膜静脉阻塞（RVO）的病例，该病例在油漆工作后病情加重。
一名60岁的男性房屋油漆工患有双侧RVO，出现了持续性CME。他接受了曲安奈德和抗VEGF玻璃体内注射治疗，后来由于双侧持续性CME，双眼接受了玻璃体切除术联合白内障手术。CME部分缓解，但在他开始油漆工作后，CME立即复发。与油漆相关的VOCs的尿代谢产物，如3-甲基马尿酸盐、扁桃酸盐和苯乙二酸盐含量非常高，与正常值相比增加了2700 - 7000%。辞去油漆工作后，患者双眼的CME有所改善。
接触与油漆相关的VOCs可能会加重CME。我们的研究结果表明，对于从事印刷和油漆行业的人员来说，减少和避免职业性接触VOCs以及定期测量尿中VOC浓度是很重要的。
