Bingöl Gülsüm, Huraıbat Ahmad, Ayduk Gövdeli Elif, Ser Özgür Selim, Ünlü Serkan, Çelik Murat, Bulut Leyla, Özden Özge, Özmen Emre, Kılıçkesmez Kadriye
Department of Cardiology, Arel University Medicine Faculty, 34010 Istanbul, Turkey.
Department of Cardiology, Memorial Bahcelievler Hospital, 34180 Istanbul, Turkey.
J Clin Med. 2025 Feb 24;14(5):1501. doi: 10.3390/jcm14051501.
: Homoarginine is a cationic amino acid derived from lysine. Evidence indicates that low-circulating homoarginine concentration is a risk factor for cardiovascular disease and all-cause mortality. A reduction in homoarginine concentrations has been observed in patients with ischemic heart disease, ischemic stroke, ischemic heart disease, and heart failure. The SYNTAX score (SS), an angiographic scoring system, defines the grade and complexity of coronary artery disease (CAD). The objective of this study was to evaluate the relationship between homoarginine level and the severity of CAD according to the SYNTAX score in patients with ST-segment elevation myocardial infarction (STEMI). : A total of 67 subjects were enrolled into the study with the diagnosis of STEMI of those who underwent coronary angiography. STEMI patients were divided into two groups: low-medium SYNTAX score ≤ 14 (35 patients) and high SYNTAX score > 14 (32 patients). : Within the high SS group, serum homoarginine levels were markedly lower (2 ± 0.9 vs. 1.3 ± 0.7; = 0.001). Homoarginine levels and SS showed a significant negative correlation in entire study cohort In multivariate regression analysis, serum homoarginine levels along with serum urea levels were significantly associated with having higher SS (OR 1.073 = 0.049 and OR 0.346, = 0.012, respectively). : In conclusion, the diminished plasma homoarginine level emerges as an independent predictor of high atherosclerotic burden among STEMI patients. To the best of our knowledge, this is the first study to demonstrate the relationship between homoarginine and coronary artery complexity.
高精氨酸是一种由赖氨酸衍生而来的阳离子氨基酸。有证据表明，循环中高精氨酸浓度低是心血管疾病和全因死亡率的一个危险因素。在患有缺血性心脏病、缺血性中风、缺血性心脏病和心力衰竭的患者中，已观察到高精氨酸浓度降低。SYNTAX评分（SS）是一种血管造影评分系统，用于定义冠状动脉疾病（CAD）的分级和复杂性。本研究的目的是根据ST段抬高型心肌梗死（STEMI）患者的SYNTAX评分，评估高精氨酸水平与CAD严重程度之间的关系。：共有67名诊断为STEMI且接受了冠状动脉造影的受试者纳入本研究。STEMI患者分为两组：低-中SYNTAX评分≤14（35例患者）和高SYNTAX评分>14（32例患者）。：在高SS组中，血清高精氨酸水平明显较低（2±0.9对1.3±0.7；P=0.001）。在整个研究队列中，高精氨酸水平与SS呈显著负相关。在多变量回归分析中，血清高精氨酸水平以及血清尿素水平与较高的SS显著相关（OR分别为1.073，P=0.049和OR为0.346，P=0.012）。：总之，血浆高精氨酸水平降低是STEMI患者高动脉粥样硬化负担的独立预测因素。据我们所知，这是第一项证明高精氨酸与冠状动脉复杂性之间关系的研究。
