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A novel neuroprotective mechanism of selegiline by suppressing the pro-apoptotic activity of protein disulfide isomerase.

作者信息

Xie Yuting, Chen Bing, Luo Piao, Huang Jingnan, Wang Jigang, Sun Jichao, Liang Zhen

机构信息

Department of Geriatrics, Guangdong Provincial Clinical Research Center for Geriatrics, Shenzhen Clinical Research Center for Geriatrics, Shenzhen People's Hospital (The First Affiliated Hospital, Southern University of Science and Technology; The Second Clinical Medical College, Jinan University), Shenzhen, Guangdong, China.

School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong, China.

出版信息

Mol Biomed. 2025 Mar 17;6(1):16. doi: 10.1186/s43556-025-00255-w.

DOI:10.1186/s43556-025-00255-w
PMID:40095124
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11914425/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b736/11914425/ba7bd6a39b0e/43556_2025_255_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b736/11914425/ba7bd6a39b0e/43556_2025_255_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b736/11914425/ba7bd6a39b0e/43556_2025_255_Fig1_HTML.jpg

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本文引用的文献

1
Rasagiline and selegiline modulate mitochondrial homeostasis, intervene apoptosis system and mitigate α-synuclein cytotoxicity in disease-modifying therapy for Parkinson's disease.雷沙吉兰和司来吉兰调节线粒体稳态，干预细胞凋亡系统，并减轻帕金森病疾病修饰治疗中α-突触核蛋白的细胞毒性。
J Neural Transm (Vienna). 2020 Feb;127(2):131-147. doi: 10.1007/s00702-020-02150-w. Epub 2020 Jan 28.
2
The Unfolded Protein Response and the Role of Protein Disulfide Isomerase in Neurodegeneration. unfolded 蛋白反应和蛋白二硫键异构酶在神经退行性变中的作用。
Front Cell Dev Biol. 2016 Jan 8;3:80. doi: 10.3389/fcell.2015.00080. eCollection 2015.
3
Small molecule-induced oxidation of protein disulfide isomerase is neuroprotective.
小分子诱导的蛋白质二硫键异构酶氧化具有神经保护作用。
Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):E2245-52. doi: 10.1073/pnas.1500439112. Epub 2015 Apr 6.
4
Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteins.蛋白质二硫键异构酶抑制剂抑制错误折叠蛋白诱导的细胞凋亡。
Nat Chem Biol. 2010 Dec;6(12):900-6. doi: 10.1038/nchembio.467. Epub 2010 Oct 31.
5
The human PDI family: versatility packed into a single fold.人类蛋白质二硫键异构酶家族：集多种功能于单一结构域。
Biochim Biophys Acta. 2008 Apr;1783(4):535-48. doi: 10.1016/j.bbamcr.2007.11.010. Epub 2007 Dec 3.