大剂量甲氨蝶呤治疗头颈部癌的结果
Results of treatment of head and neck carcinoma with high dose methotrexate.
作者信息
Bell R, Sullivan J R, Fleming W B, Grey P A, Millar H S
机构信息
Department of Haemato-Oncology, Royal Melbourne Hospital, Victoria, Australia.
出版信息
Clin Exp Pharmacol Physiol Suppl. 1979;5:23-7.
PMID:400970
Abstract
Forty four patients with squamous cell carcinoma of the head and neck from a variety of primary sites were treated with high dose methotrexate with folinic acid rescue from 1975 to 1977. The overall response rate was 66%. Response duration was short with a mean of 16 weeks. The usefulness of this technique in the treatment of head and neck cancer is discussed.
摘要
1975年至1977年期间，对44例来自不同原发部位的头颈部鳞状细胞癌患者采用大剂量甲氨蝶呤并辅以亚叶酸解救进行治疗。总体缓解率为66%。缓解持续时间较短，平均为16周。本文讨论了该技术在头颈部癌治疗中的实用性。
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