McGinley S, Centra M, Lysz T W
J Neurosci Res. 1985;13(4):563-7. doi: 10.1002/jnr.490130411.
The effect of inhibiting endogenous brain thromboxane (TXB2) on pentylenetetrazole-induced seizures was studied using the thromboxane synthetase inhibitors OKY-1581 (20 mg/kg) and UK 38,485 (50 mg/kg). Both compounds selectively decreased (greater than 90%) TXB2 production in brain measured after 2 min of convulsive activity but had no effect on brain PGE2, PGF2 alpha, or 6-keto-PGF1 alpha. No effect of these agents on the tonic seizure threshold was observed, whereas 10 mg/kg ip indomethacin, an agent which inhibits both TXB2 and prostaglandin production, reduced the tonic seizure threshold from 78 +/- 2.6 mg/kg in controls to 62 +/- 3.7 mg/kg. Thus, this study concludes that the availability of TXB2 with convulsant activity is unlikely to be a factor in altering tonic seizure activity observed with indomethacin.
使用血栓素合成酶抑制剂OKY - 1581（20毫克/千克）和UK 38,485（50毫克/千克）研究了抑制内源性脑血栓素（TXB2）对戊四氮诱导癫痫发作的影响。两种化合物在惊厥活动2分钟后均选择性降低（大于90%）脑中TXB2的产生，但对脑PGE2、PGF2α或6 - 酮 - PGF1α无影响。未观察到这些药物对强直发作阈值有影响，而腹腔注射10毫克/千克消炎痛（一种同时抑制TXB2和前列腺素产生的药物）可使强直发作阈值从对照组的78±2.6毫克/千克降至62±3.7毫克/千克。因此，本研究得出结论，具有惊厥活性的TXB2的可用性不太可能是改变消炎痛所观察到的强直发作活动的一个因素。
