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Checkpoint inhibitor therapy in immunosuppressed patients with Merkel cell carcinoma: not all immunosuppression is created equal.免疫抑制的默克尔细胞癌患者的检查点抑制剂疗法：并非所有免疫抑制情况都是相同的。
BMJ Oncol. 2025 Mar 6;4(1):e000695. doi: 10.1136/bmjonc-2024-000695. eCollection 2025.
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Cytokines, Chemokines, and Other Biomarkers of Response for Checkpoint Inhibitor Therapy in Skin Cancer.皮肤癌中检查点抑制剂治疗反应的细胞因子、趋化因子及其他生物标志物
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本文引用的文献

1
A systematic review and meta-analysis of observational studies and uncontrolled trials reporting on the use of checkpoint blockers in patients with cancer and pre-existing autoimmune disease.一项系统性综述和荟萃分析，观察性研究和非对照试验报告了在患有癌症和预先存在的自身免疫性疾病的患者中使用检查点抑制剂的情况。
Eur J Cancer. 2024 Aug;207:114148. doi: 10.1016/j.ejca.2024.114148. Epub 2024 May 31.
2
First-line avelumab treatment in patients with metastatic Merkel cell carcinoma: 4-year follow-up from part B of the JAVELIN Merkel 200 study.在转移性 Merkel 细胞癌患者中进行一线avelumab 治疗：JAVELIN Merkel 200 研究 B 部分的 4 年随访结果。
ESMO Open. 2024 May;9(5):103461. doi: 10.1016/j.esmoop.2024.103461. Epub 2024 May 13.
3
Efficacy of immune checkpoint inhibitors for the treatment of advanced melanoma in patients with concomitant chronic lymphocytic leukemia.免疫检查点抑制剂治疗合并慢性淋巴细胞白血病的晚期黑色素瘤患者的疗效。
Ann Oncol. 2023 Sep;34(9):796-805. doi: 10.1016/j.annonc.2023.06.007. Epub 2023 Jul 4.
4
Three-year survival, correlates and salvage therapies in patients receiving first-line pembrolizumab for advanced Merkel cell carcinoma.接受一线帕博利珠单抗治疗的晚期 Merkel 细胞癌患者的 3 年生存率、相关因素和挽救治疗。
J Immunother Cancer. 2021 Apr;9(4). doi: 10.1136/jitc-2021-002478.
5
The Genomic Landscape of Merkel Cell Carcinoma and Clinicogenomic Biomarkers of Response to Immune Checkpoint Inhibitor Therapy.默克尔细胞癌的基因组特征及免疫检查点抑制剂治疗反应的临床基因组生物标志物。
Clin Cancer Res. 2019 Oct 1;25(19):5961-5971. doi: 10.1158/1078-0432.CCR-18-4159. Epub 2019 Aug 9.
6
Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU features.195例默克尔细胞癌确诊时的临床特征：AEIOU特征
J Am Acad Dermatol. 2008 Mar;58(3):375-81. doi: 10.1016/j.jaad.2007.11.020.

Checkpoint inhibitor therapy in immunosuppressed patients with Merkel cell carcinoma: not all immunosuppression is created equal.

作者信息

Brohl Andrew S

机构信息

Sarcoma Department and Department of Cutaneous Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.

出版信息

BMJ Oncol. 2025 Mar 6;4(1):e000695. doi: 10.1136/bmjonc-2024-000695. eCollection 2025.

DOI:10.1136/bmjonc-2024-000695
PMID:40099005
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11911669/
Abstract
摘要