中性氨基酸跨人红细胞膜的转运。

Transport of neutral amino acids across the human red blood cell membrane.

Rosenberg R, Rafaelsen O J

Psychochemistry Institute, University of Copenhagen Rigshospitalet, Denmark.

Prog Neuropsychopharmacol. 1979;3(4):377-81. doi: 10.1016/0364-7722(79)90049-3.

Abstract

Genetic markers are important in the search for genetically transmitted entities related to clinical nosology with implications for etiology, prophylaxis and treatment. 2. Rafaelsen (1976) has proposed a membrane transport model of affective disorders focusing on phase-independent transport deficiencies. 3. The transport of some neutral amino acids (L-leucine, L-phenylalanine and L-tryptophan) has been studied in the human erythrocyte at 25 degrees C. 4. A group- and a tryptophan-specific amino acid transport system have been described. 5. The relation to the model of Rafaelsen is discussed. 6. It is concluded that clinical studies should be undertaken to test whether these biological characteristics consistent with a specific theory are biological-etiological markers.

摘要

基因标记对于寻找与临床疾病分类学相关的遗传传递实体非常重要，这对病因学、预防和治疗具有重要意义。2. 拉费尔森（1976年）提出了一种情感障碍的膜转运模型，该模型侧重于与阶段无关的转运缺陷。3. 已在25摄氏度下对人红细胞中某些中性氨基酸（L-亮氨酸、L-苯丙氨酸和L-色氨酸）的转运进行了研究。4. 已经描述了一种基团特异性和一种色氨酸特异性氨基酸转运系统。5. 讨论了与拉费尔森模型的关系。6. 得出的结论是，应进行临床研究，以测试这些与特定理论一致的生物学特征是否为生物病因学标记。