Tsutsui H, Tomoike H, Araki H, Nakamura M
Jpn Heart J. 1985 Mar;26(2):191-5. doi: 10.1536/ihj.26.191.
Despite a large number of papers concerning coronary spasm, its mechanism still remains unsolved. Several cases have been reported in which coronary spasm was triggered by allergy. Since histamine is one of the causative substances released in allergic reactions, we speculated on some involvement of an allergic mechanism in the pathogenesis of coronary spasm. We retrospectively examined by questionnaire the incidence of allergic history in patients with variant angina (n = 47) and compared it with that in patients with non-ischemic heart diseases (n = 83). We could not find any relationship between coronary spasm and allergy. Furthermore, we have not experienced any case in which myocardial ischemia was provoked by an allergic reaction. Accordingly, allergy could not be a major cause of coronary spasm in our present experience.
尽管有大量关于冠状动脉痉挛的论文，但它的发病机制仍然未得到解决。已有数例报告称冠状动脉痉挛由过敏引发。由于组胺是过敏反应中释放的致病物质之一，我们推测过敏机制在冠状动脉痉挛的发病过程中可能起到一定作用。我们通过问卷调查对变异型心绞痛患者（n = 47）的过敏史发生率进行了回顾性研究，并与非缺血性心脏病患者（n = 83）的过敏史发生率进行了比较。我们未发现冠状动脉痉挛与过敏之间存在任何关联。此外，我们也未曾遇到过因过敏反应诱发心肌缺血的病例。因此，根据我们目前的经验，过敏并非冠状动脉痉挛的主要病因。
