Zhang Jiaqing, Jin Ling, Chen Qianyun, Wang Decai, Chen Xiang, Li Yuting, Qu Yabin, Lin Rong, He Mingguang, Morgan Ian G, Luo Lixia, Zeng Yangfa, Han Xiaotong
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, Guangdong, China.
Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China.
Invest Ophthalmol Vis Sci. 2025 Mar 3;66(3):36. doi: 10.1167/iovs.66.3.36.
To investigate changes in the crystalline lens before and after the onset of myopia.
This prospective cohort study was conducted in Guangzhou, Guangdong, China. Participants were initially emmetropic or hyperopic at baseline and were followed for 5 years, during which they were categorized into two groups: those who developed myopia (newly developed myopes [NDM]; n = 1669) and those who remained hyperopic or emmetropic (persistent nonmyopes [PNM]; n = 4259). Changes in spherical equivalent refraction (SER), axial length, lens thickness, and lens power were analyzed from 5 years before to 4 years after myopia onset. Age-related trends in SER and biometric parameters were compared between the PNM and NDM groups.
The mean age of the included children at baseline was 7.61 ± 2.68 years (range, 3-14 years), with 3272 boys (55.20%). Compared with the PNM group, the NDM group exhibited a faster myopic refraction shift, accelerated axial elongation, and a more rapid reduction in lens thickness and power. Changes in SER and axial length peaked at 1 year before myopia onset (P < 0.001), but lens thickness and power remained relatively stable before myopia onset. The rate of change in SER and biometric parameters all slowed after myopia onset. In the PNM group, lens thickness decreased before age 11 and increased thereafter, whereas lens power decreased continuously, with a slower rate of decline after 11 years of age.
SER and axial length demonstrate accelerated changes 1 year before myopia onset, whereas lens thickness and power remain largely stable before and after myopia onset, with changes primarily associated with age.
研究近视发生前后晶状体的变化。
本前瞻性队列研究在中国广东省广州市进行。参与者在基线时最初为正视或远视，并随访5年，在此期间他们被分为两组：发生近视的人群（新发生近视者[NDM]；n = 1669）和仍为远视或正视的人群（持续非近视者[PNM]；n = 4259）。分析近视发生前5年至发生后4年期间等效球镜度（SER）、眼轴长度、晶状体厚度和晶状体屈光力的变化。比较PNM组和NDM组SER及生物测量参数的年龄相关趋势。
纳入儿童在基线时的平均年龄为7.61±2.68岁（范围3 - 14岁），其中男孩3272名（55.20%）。与PNM组相比，NDM组表现出更快的近视性屈光偏移、加速的眼轴伸长以及晶状体厚度和屈光力更快速的降低。SER和眼轴长度的变化在近视发生前1年达到峰值（P < 0.001），但晶状体厚度和屈光力在近视发生前保持相对稳定。近视发生后，SER和生物测量参数的变化率均减慢。在PNM组中，晶状体厚度在11岁前下降，之后增加，而晶状体屈光力持续下降，11岁后下降速度减慢。
SER和眼轴长度在近视发生前1年显示出加速变化，而晶状体厚度和屈光力在近视发生前后基本保持稳定，变化主要与年龄相关。
