Graves Scott S, Zellmer Eustacia, Storb Rainer
Fred Hutchinson Cancer Center, Seattle, WA, USA.
University of Washington School of Medicine, Seattle, WA, USA.
Methods Mol Biol. 2025;2907:207-236. doi: 10.1007/978-1-0716-4430-0_10.
Graft-versus-host disease (GVHD) is a risk of hematopoietic cell transplantation (HCT) in the clinical setting. The acute form of the disease is well managed, but the chronic form is more problematic. The canine HCT model, instrumental in establishing successful clinical HCT protocols, reproducibly recapitulates the clinical manifestations of GVHD. Thus, therapies for the prevention and treatment of GVHD in the canine model may be applicable to the clinic. Here, we present the methods necessary to establish both acute and chronic GVHD models in dogs.
移植物抗宿主病（GVHD）是临床环境中造血细胞移植（HCT）的一种风险。该疾病的急性形式得到了很好的控制，但慢性形式则更成问题。犬类造血细胞移植模型在建立成功的临床造血细胞移植方案中发挥了重要作用，可重复性地概括移植物抗宿主病的临床表现。因此，犬类模型中预防和治疗移植物抗宿主病的疗法可能适用于临床。在此，我们介绍在犬类中建立急性和慢性移植物抗宿主病模型所需的方法。
